Chemical Structure : KVS0001
CAS No.:
KVS0001
(KVS 0001, KVS-0001)
Catalog No.: PC-21705Not For Human Use, Lab Use Only.
KVS0001 is a specific and bioavailable small molecule inhibitor of SMG1 kinase, disrupts nonsense mediated decay (NMD).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
KVS0001 is a specific and bioavailable small molecule inhibitor of SMG1 kinase, disrupts nonsense mediated decay (NMD).
KVS0001 is highly selective against the other 246 protein or lipid kinases up to 1 uM.
KVS0001 substantially decreases the amount of phosphorylated UPF1, the downstream target of SMG1 kinase activity in NCI-H358 and LS180 cells.
KVS0001 causes MHC class I display of hidden neoantigens, increases the expression of TP53 in cancer cell lines, NCI-H716 and NCI-H2228.
KVS0001 (30 mg/kg) impacts tumor growth in syngeneic models.
KVS0001 elevates the expression of transcripts and proteins resulting from truncating mutations in vivo and in vitro.
Physicochemical Properties
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M.Wt
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579.08
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Formula
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C27H27ClN8O3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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1-(4-(4-(2-((4-chloro-3-(piperazin-1-ylsulfonyl)phenyl)amino)pyrimidin-4-yl)pyridin-2-yl)phenyl)-3-methylurea
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References
1. Ashley L Cook, et al. bioRxiv. 2023 Dec 29:2023.12.28.573594.
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