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G3BP inhibitor b

Chemical Structure : G3BP inhibitor b

CAS No.: 3036029-78-1

G3BP inhibitor b (G3Ib)

Catalog No.: PC-21745Not For Human Use, Lab Use Only.

G3BP inhibitor b (G3Ib) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.15 uM, blocks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.

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    Biological Activity

    G3BP inhibitor b (G3Ib) is a specific, peptide mimetic inhibitor of RNA-binding proteins G3BP1/2 with SPR Kd value of 0.15 uM, blocks the association of G3BP with its binding partners and inhibits condensation of G3BP both in vitro and in live cells.
    G3BP inhibitor b (G3Ib) binds the NTF2L domain of G3BP1, disrupts in vitro condensation of RNA, G3BP1, and caprin 1.
    G3BP inhibitor b (G3Ib) (50 uM) inhibits stress granule formation in HeLa cells about 82%.
    G3BP inhibitor b (G3Ib) (50 uM) reduces eIF3η, PABPC1, and FXR1 puncta, indicating disassembly of stress granules beyond simple extraction of G3BP1, does not influence the rate of translation in cells.
    G3BP inhibitor b (G3Ib) prevents the formation of stress granules and dissolves preformed stress granules in human iPSC-derived neurons, dissolves stress granules formed in response to expression of a disease-causing VCP mutant.

    Physicochemical Properties

    M.Wt 606.81
    Formula C35H50N4O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-((S)-3-hydroxy-3-methyl-1-oxo-1-(((2S,3S)-1-oxo-1-(((R)-1-oxo-1-((R)-2-phenylpyrrolidin-1-yl)propan-2-yl)amino)-3-phenylbutan-2-yl)amino)butan-2-yl)-4,4-dimethylpentanamide

    References

    1. Freibaum BD, et al. J Cell Biol. 2024 Mar 4;223(3):e202308083.

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