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L6H21

Chemical Structure : L6H21

CAS No.: 24533-47-9

L6H21

Catalog No.: PC-21724Not For Human Use, Lab Use Only.

L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.
L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages with IC50 of 6.58 and 8.59 μM, respectively.
L6H21 inhibits EtOH + LPS-induced apoptosis and mitochondrial damage in RAW264.7 cells.
L6H21 attenuates EtOH + LPS-induced ROS formation and TLR4–NF-κB activation, and decreases NLRP3 inflammasome activation.
L6H21 (10 mg/kg, Oral gavage, daily) effectively inhibits EtOH + LPS-induced hepatic fat accumulation, hepatic steatosis and liver injury in vivo.

Physicochemical Properties

M.Wt 298.34
Formula C18H18O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one

References

1. Kong X, et al. Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671.

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