Chemical Structure : L6H21
CAS No.:
24533-47-9
L6H21
Catalog No.: PC-21724Not For Human Use, Lab Use Only.
L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
L6H21 is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor with binding KD value of 33.3 uM, blocks the formation of the LPS-TLR4/MD-2 complex.
L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages with IC50 of 6.58 and 8.59 μM, respectively.
L6H21 inhibits EtOH + LPS-induced apoptosis and mitochondrial damage in RAW264.7 cells.
L6H21 attenuates EtOH + LPS-induced ROS formation and TLR4–NF-κB activation, and decreases NLRP3 inflammasome activation.
L6H21 (10 mg/kg, Oral gavage, daily) effectively inhibits EtOH + LPS-induced hepatic fat accumulation, hepatic steatosis and liver injury in vivo.
Physicochemical Properties
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M.Wt
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298.34
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Formula
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C18H18O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
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References
1. Kong X, et al. Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671.
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