SKOG102 | OLIG2 inhibitor | Probechem Biochemicals

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Chemical Structure : SKOG102

SKOG102 (SKOG 102)

Catalog No.: PC-21701Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.
SKOG102 affects expression of direct genetic targets of OLIG2.
SKOG102 (20 mg/kg) significantly attenuated tumor growth in in vivo studies to a GBM patient derived cancer stem cell (GBM4 line) based orthotopic model.

Physicochemical Properties

M.Wt	422.36
Formula	C19H25Cl2N7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)amino)-6-methyl-2-pyrimidinyl)guanidine

References

1. Igor F Tsigelny, et al. Oncotarget. 2017 Apr 4;8(14):22370-22384.

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SKOG102 (SKOG 102)

Biological Activity

Physicochemical Properties

References

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