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Chemical Structure : SKOG102
Catalog No.: PC-21701Not For Human Use, Lab Use Only.
SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.
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SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.
SKOG102 affects expression of direct genetic targets of OLIG2.
SKOG102 (20 mg/kg) significantly attenuated tumor growth in in vivo studies to a GBM patient derived cancer stem cell (GBM4 line) based orthotopic model.
| M.Wt | 422.36 | |
| Formula | C19H25Cl2N7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Igor F Tsigelny, et al. Oncotarget. 2017 Apr 4;8(14):22370-22384.
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