Catalog No.: PC-21701Not For Human Use, Lab Use Only.
SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.
SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.
SKOG102 affects expression of direct genetic targets of OLIG2.
SKOG102 (20 mg/kg) significantly attenuated tumor growth in in vivo studies to a GBM patient derived cancer stem cell (GBM4 line) based orthotopic model.
