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Cat. No. Product Name Information
PC-49458

KL101

CRY1 stabilizer

KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1).
PC-49457

PGP inhibitor CP1

PGP inhibitor

PGP inhibitor CP1 is a specific small-molecule phosphoglycolate phosphatase (PGP) inhibitor with IC50 of 0.39 uM (hPGP), blocks PGP-dependent glycolytic flux in mammalian cells.
PC-49456

CRY1 destabilizer M47

CRY1 destabilizer

CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination.
PC-49448

Eliglustat

GCS inhibitor

Eliglustat (GENZ 112638) is a ceramide analog and an orally bioavailable inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase) with IC50 of 20 nM in free-cell assays.
PC-49442

Connexin hemichannel inhibitor D4

Connexin hemichannel inhibitor

Connexin hemichannel inhibitor D4 is an orally available small molecule inhibitor of connexin hemichannels (Cx hemichannel).
PC-49430

SGPL1 inhibitor THI

SGPL1 inhibitor

2-acetyl-5-tetrahydroxybutyl imidazole (SGPL1 inhibitor THI) is a small molecule inhibitor of sphingosine-1- phosphate lyase (SGPL1) reduced cell apoptosis in different in vitro huntington's disease (HD) models.
PC-49429

Larazotide acetate

Zonulin inhibitor

Larazotide acetate (AT1001) is a synthetic, competitive octapeptide inhibitor of zonulin, acts as a tight junction regulator to restore intestinal barrier function.
PC-49422

Transthyretin stabilizer M-23

Transthyretin stabilizer

Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.
PC-49419

KIO-100

DHODH inhibitor

KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM).
PC-49413

UNC-CA157

COQ8A inhibitor

UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B.
PC-49409

ZHAWOC8697

SENP inhibitor

ZHAWOC8697 is a small molecule dual inhibitor of sentrin-specific protease SENP1 and SENP2 with IC50 of 8.6 and 2.3 uM, respectively, a valuable tool for the study of SUMOylation processes.
PC-49405

PITPNM3 inhibitor C8018-7840

PITPNM3 inhibitor

PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion.

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