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SB1501

Chemical Structure : SB1501

CAS No.: 2757411-32-6

SB1501 (SB 1501)

Catalog No.: PC-20138Not For Human Use, Lab Use Only.

SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo.

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    Biological Activity

    SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo.
    SB1501 (40 μM) reduces the size and fat accumulation of lipid droplets (LDs) in 3T3-L1 adipocytes.
    SB1501 increases mitochondrial biogenesis and fatty acid oxidation (FAO) with upregulation of PGC-1α-UCP1 regulatory axis, which leads to reduced fat accumulation and demand for lipid storage capacity in 3T3-L1 adipocyte.
    SB1501 increases mitochondrial function and morphology in 3T3-L1 adipocytes.
    SB1501 (10 mg/kg, 5 weeks, oral) exhibits anti-obesity effects in a db/db mouse model.
    SB1501 significantly increased the mRNA levels of Pgc-1α and Ucp1 in inguinal white adipose tissue.

    Physicochemical Properties

    M.Wt 349.39
    Formula C20H19N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-2,2-dimethyl-2H-chromen-7-ol

    References

    1. Jo A, et al. ChemMedChem. 2021 Apr 8;16(7):1104-1115.

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