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MitoCKi

Chemical Structure : MitoCKi

CAS No.:

MitoCKi (CKi-26)

Catalog No.: PC-20155Not For Human Use, Lab Use Only.

MitoCKi (Creatine kinase inhibitor CKi-26) is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 185 nM, depletes creatine phosphagen energetics in cells.

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    Biological Activity

    MitoCKi (Creatine kinase inhibitor CKi-26) is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 185 nM, depletes creatine phosphagen energetics in cells.
    MitoCKi (10-20 uM) rapidly and selectively depletes creatine phosphate, and drives toxicity selectively in CK-dependent acute myeloid leukemia.
    MitoCKi selectively engages the active site cysteine (Cys283) of CKs in cells. MitoCKi inhibits cell viability in UCSD-AML1 cells with EC50 of 1.8 uM.

    Physicochemical Properties

    M.Wt 642.20
    Formula C38H43ClN2O3P+
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (9-(4-(2-chloroacetyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxamido)nonyl)triphenylphosphonium

    References

    1. Narek Darabedian, et al. Nat Chem Biol. 2023 Feb 23. doi: 10.1038/s41589-023-01273-x.

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