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Cat. No. Product Name Information
PC-35460

ATR-101 free base

ACAT1 inhibitor

ATR-101 (PD-132301, Nevanimibe) is a selective and potent inhibitor of ACAT1 with IC50 of 52 nM.
PC-35451

Foslinanib sodium

TRAP1 inhibitor

Foslinanib (TRX-818, CVM-1118) sodium is an orally bioavailable agent with potential antineoplastic and anti-vasculogenic mimicry (VM) activities, promotes apoptosis and inhibits vasculogenic mimicry via targeting TRAP1.
PC-35441

Cimlanod

HNO donor

Cimlanod is a second-generation nitroxyl (HNO) donor, delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream, shows positive lusitropic and inotropic as well as vasodilatory effects.
PC-35430

BIO124

PICK1-GluA2 inhibitor

BIO124 (BIO-124) is a modest inhibitor of the PICK1-GluA2 interaction with IC50 of 0.51 uM in FP assays, binds to the PDZ domain of PICK1.
PC-35415

Desmethyl dabrafenib

Desmethyl dabrafenib (GSK2167542, Dabrafenib metabolite M8) is the desmethyl- metabolic byproduct of Dabrafenib, ameliorates developmental pathologies of Kabuki Syndrome in vivo..
PC-35412

GAK inhibitor 49

GAK inhibitor

GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K).
PC-35411

GAK inhibitor 12r

GAK inhibitor

GAK inhibitor 12r is a higghly potent, selective inhibitor of cyclin G-associated kinase (GAK) with Kd of 89 nM.
PC-35410

IGS-1.76

NCS-1/Ric8a inhibitor

IGS-1.76 is a small molecule inhibitor of human NCS-1/Ric8a interaction with affinity of 1.25 uM (hNCS-1).
PC-35386

FTBMT

GPR52 agonist

FTBMT (TP024) is a novel selective GPR52 agonist, increases intracellular cAMP levels in CHO cells expressing human, mouse, or rat GPR52, with pEC50 of 7.03, 6.85, and 6.87M, respectively.
PC-35376

SOD1-Derlin-1 inhibitor 56-59

SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assays.
PC-35371

Edonerpic maleate

CRMP2 inhibitor, Aβ inhibitor

Edonerpic maleate (T-817MA) is a neurotrophic agent that can protects neuronal cells and modifies their morphology, binds to collapsin-response-mediator-protein 2 (CRMP2) and inhibits amyloid-β peptides (Aβ).
PC-35366

Lipofermata

Fatty acid transport inhibitor

Lipofermata (CB16.2 aka) is a specific fatty acid transport (FATP) inhibitor, blocks human FATP2-mediated fatty acid uptake (IC50=4.84 uM in Caco-2 cells) without impacting other cellular functions.

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