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AP20187

Chemical Structure : AP20187

CAS No.: 195514-80-8

AP20187 (AP-20187, AP 20187)

Catalog No.: PC-35968Not For Human Use, Lab Use Only.

AP20187 (AP-20187, AP 20187) is a cell-permeable, semisynthetic bivalent ligand (dimerizer) of FK506-binding protein (FKBP F36V).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AP20187 (AP-20187, AP 20187) is a cell-permeable, semisynthetic bivalent ligand (dimerizer) of FK506-binding protein (FKBP F36V).
AP20187 potently inhibits the differentiation of transfected myoblasts in the absence of bFGF, blocks myotube formation and myosin heavy chain expression and stimulates MAP kinase phosphorylation in transfected cells.
AP20187 dramatically suppressed LNCaP tumor growth in nude mice and led to a significantly increased host survival.

Physicochemical Properties

M.Wt 1482.773
Formula C82H107N5O20
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,1'R)-(((((2-((dimethylamino)methyl)propane-1,3-diyl)bis(azanediyl))bis(2-oxoethane-2,1-diyl))bis(oxy))bis(3,1-phenylene))bis(3-(3,4-dimethoxyphenyl)propane-1,1-diyl) (2S,2'S)-bis(1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate)

References

1. Whitney ML, et al. J Biol Chem. 2001 Nov 2;276(44):41191-6.

2. Xie X, et al. Cancer Res. 2001 Sep 15;61(18):6795-804.

3. Feng H, et al. Blood. 2001 Jun 1;97(11):3505-12.

4. Richard RE, et al. Mol Ther. 2004 Oct;10(4):730-40.

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