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MitoBloCK-11

Chemical Structure : MitoBloCK-11

CAS No.: 413606-16-3

MitoBloCK-11 (MB-11, MitoBloCK 11)

Catalog No.: PC-35923Not For Human Use, Lab Use Only.

MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20.

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Biological Activity

MitoBloCK-11 (MB-11) is a s mall molecule inhibitor of mitochondrial protein import possibly acts through transport protein Seo1, but not Tom70 or Tom20.
MitoBloCK-11 inhibits precursor proteins that contain hydrophobic segments, confers growth in media lacking uracil in a specific manner and affects zebrafish development.

Physicochemical Properties

M.Wt 434.264
Formula C17H12BrN3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-((4-bromonaphthalen-1-yl)oxy)-N'-((5-nitrothiophen-2-yl)methylene)acetohydrazide

References

1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA.

2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442.

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