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Chemical Structure : MitoBloCK-10
CAS No.: 394694-98-5
Catalog No.: PC-35922Not For Human Use, Lab Use Only.
MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway.
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|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $358 | In stock | |
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| 100 mg | Get quote |
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MitoBloCK-10 (MB-10) is a potential attenuator of protein import into mitochondria via targeting Tim44, inhibits the import of substrates that use the TIM23 import pathway.
MitoBloCK-10 targets Tim44 and mutations in the α4 helix of the C-terminal domain of Tim44 confer resistence to MitoBloCK-10 (MB-10).
MitoBloCK-10 (MB-10) inhibits Tim44 binding to the precursor and to Hsp70, but not other component of the PAM complex.
MitoBloCK-10 inhibits Hela cell viability with IC50 of 17.2 uM in MTT assays, impairs cardiac development and induces apoptosis in zebrafish.
| M.Wt | 293.272 | |
| Formula | C12H8FN3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide |
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1. Conti, M. (2018). Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy. UCLA.
2. Miyata N, et al. J Biol Chem. 2017 Mar 31;292(13):5429-5442.
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