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CSRM617 hydrochloride

Chemical Structure : CSRM617 hydrochloride

CAS No.: 1353749-74-2

CSRM617 hydrochloride (CSRM-617)

Catalog No.: PC-35956Not For Human Use, Lab Use Only.

CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.
CSRM617 inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2.
CSRM617 significantly downregulates PEG10 protein levels in tumors from mice, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.

Physicochemical Properties

M.Wt 291.688
Formula C10H14ClN3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride

References

1. Rotinen M, et al. Nat Med. 2018 Dec;24(12):1887-1898.

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