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Chemical Structure : CSRM617 hydrochloride
CAS No.: 1353749-74-2
Catalog No.: PC-35956Not For Human Use, Lab Use Only.
CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.
CSRM617 inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2.
CSRM617 significantly downregulates PEG10 protein levels in tumors from mice, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.
| M.Wt | 291.688 | |
| Formula | C10H14ClN3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride |
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1. Rotinen M, et al. Nat Med. 2018 Dec;24(12):1887-1898.
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