| Cat. No. |
Product Name |
Information |
| PC-49767 |
CNS-11g
Alpha-synuclein inhibitor
|
CNS-11g is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core. |
| PC-49766 |
CNS-11
Alpha-synuclein inhibitor
|
CNS-11 is a small molecules capable of disassembling preformed alpha-synuclein fibrils, may exert it's disaggregating effects on the N terminus of the fibril core. |
| PC-49756 |
NB-598 maleate
Squalene epoxidase inhibitor
|
NB-598 (NB598) is a potent competitive inhibitor of squalene epoxidase (SQLE, SE, squalene monooxygenase) with IC50 of 4.4 nM (rat SE), inhibits microsomal squalene epoxidase from dog liver and Hep G2 cells with IC50 of 2.0 and 0.75 nM, respectively. |
| PC-49755 |
MM0299 analog 13
Lanosterol synthase inhibitor
|
MM0299 analog 13 (MM 0299 derivative 13) is a potent, selective, orally bioavailable, brain-penetrant inhibitor of lanosterol synthase (LSS, competition EC50=28.7 nM) with anti-proliferative activity. |
| PC-49754 |
MM0299
Lanosterol synthase inhibitor
|
MM0299 (MM 0299) is a potent, selective inhibitor of lanosterol synthase (LSS, competition EC50=1.97 nM) with anti-proliferative activity, inhibits Mut6 cell growth (IC50=18.2 nM) and induces the synthesis of 24(S),25-epoxycholesterol (EPC). |
| PC-49751 |
Cl-NIO
DDAH-1 inhibitor
|
Cl-NIO is a potent, selective inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) with Ki of 1.3 uM, > 500-fold selectivity against arginase and endothelial nitric oxide synthase. |
| PC-49743 |
M50054
Apoptosis inhibitor
|
M50054 (M 50054) is a small molecule inhibitor of apoptosis (programmed cell death), inhibits soluble human Fas ligand-induced cell death of human Fasexpressing WC8 cells with IC50 of 67 ug/mL. |
| PC-49741 |
Compound 7930079
Troponin C modulator
|
Compound 7930079 is a small molecule that increase calcium sensitivity without altering systolic calcium concentration and strengthening cardiac function, is a high affinity binder of Troponin C N-terminal domain (cNTnC) with Kd of 1.45 uM. |
| PC-49740 |
BI-6c9
Bid inhibitor
|
BI-6C9 is a specific small molecule inhibitor of BH3 interacting-domain death agonist (Bid) with Kd of 20 uM, blocks the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. |
| PC-49739 |
MS0621
EWSR1::FLI1 modulator
|
MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM). |
| PC-49731 |
trans-MiM111
Mitofusin activator
|
trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93). |
| PC-49730 |
CPR1-B
Mitofusin activator
|
CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%). |
