| Cat. No. |
Product Name |
Information |
| PC-62472 |
GGTI-286
GGTase I inhibitor
|
GGTI-286 is a CAAX peptidomimetic, potent, cell-permeable, and selective inhibitor of GGTase I with IC50 of 2 uM, 25-fold more potent than FTI-277. |
| PC-62471 |
GGTI-2147
GGTase I inhibitor
|
GGTI-2147 is a non-thiol peptidomimetic that inhibits GGTase I and blocks geranyl-geranylation of Rap1A (IC50=0.5 uM). |
| PC-62470 |
GGTI-2133
GGTase I inhibitor
|
GGTI-2133 is a cell-permeable, non-thiol peptidomimetic that acts as a potent and selective inhibitor of GGTase I (IC50=38 nM), displays 40-fold selectivity over FTase. |
| PC-62437 |
CSIC E379
UCP1/UCP2 inhibitor
|
CSIC E379 is a potent, selective uncoupling proteins UCP1/UCP2 inhibitor with EC50 of 20 uM/30 uM, respectively. |
| PC-62435 |
Cytochalasin B
Actin inhibitor, GLUT inhibitor
|
Cytochalasin B is a cell-permeable mycotoxin that inhibits network formation by actin filaments, inhibits cell movement and induces nuclear extrusion, shows Kd value of 1.4-2.2 nM for F-actin. |
| PC-62434 |
Antimycin A
Cytochrome c reductase inhibitor
|
Antimycin A is an inhibitor of cellular respiration, specifically oxidative phosphorylation, binds to the Qi site of cytochrome c reductase, disrupts the Q-cycle of enzyme turn over. |
| PC-62428 |
IMM-02
mDia-related formins agonist
|
IMM-02 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 99 nM. |
| PC-62427 |
IMM-01
mDia-related formins agonist
|
IMM-01 is a small molecule agonist of mammalian Diaphanous (mDia)-related formins that disrupts diaphanous inhibitory domain (DID) and diaphanous autoregulatory domain (DAD) interaction with IC50 of 140 nM. |
| PC-62425 |
Adhesamine
|
Adhesamine is a diaryldispirotripiperazine derivative that selectively targets cell-surface glycosaminoglycans, especially heparan sulfate, for increasing cell adhesion and growth. |
| PC-62416 |
EG1
Pax2 inhibitor
|
Pax2 inhibitor EG1 (EG1) is a potent, small molecule inhibitor of Pax2 mediated transcription activation, effectively blocks Pax2 activity and DNA binding with Kd of 1.35-1.5 uM. |
| PC-62413 |
RBPI-4
PARG inhibitor
|
RBPI-4 is a selective small molecule inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with IC50 of 3.0 uM, effectively inhibit PARG in cellular lysate. |
| PC-62412 |
PDD 00017273
PARG inhibitor
|
PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM. |
