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Chemical Structure : HJC0726
Catalog No.: PC-63105Not For Human Use, Lab Use Only.
HJC0726 (HJC-0726) is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.
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HJC0726 (HJC-0726) is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.
HJC0726 also inhibits EPAC1-mediated Rap1-GDP exchange activity.
HJC0726 does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM.
HJC0726 inhibits GEF activity of the full-length EPAC1 in the presence of 20 µM cAMP with IC50 of 2.4 uM.
| M.Wt | 365.214 | |
| Formula | C16H14Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.
2. Chen H, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.
3. Juhász T, et al. Cell Signal. 2014 Mar;26(3):468-82.
4. Zhu Y, et al. Sci Rep. 2015 Mar 20;5:9344.
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