HJC0726 | EPAC2 inhibitor | Probechem Biochemicals

Chemical Structure : HJC0726

HJC0726 (HJC-0726)

Catalog No.: PC-63105Not For Human Use, Lab Use Only.

HJC0726 (HJC-0726) is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.

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Biological Activity

HJC0726 (HJC-0726) is a potent Exchange proteins directly activated by cAMP (EPAC) inhibitor, inhibits cAMP-mediated EPAC2 GEF activity with IC50 of 1.0 uM.
HJC0726 also inhibits EPAC1-mediated Rap1-GDP exchange activity.
HJC0726 does not alter cAMP-induced type I and II PKA holoenzymes activation at 25 uM.
HJC0726 inhibits GEF activity of the full-length EPAC1 in the presence of 20 µM cAMP with IC50 of 2.4 uM.

Physicochemical Properties

M.Wt	365.214
Formula	C16H14Cl2N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-(tert-butyl)isoxazol-3-yl)-N-(3,5-dichlorophenyl)-2-oxoacetohydrazonoyl cyanide

References

1. Chen H, et al. J Med Chem. 2014 May 8;57(9):3651-65.

2. Chen H, et al. Bioorg Med Chem Lett. 2012 Jun 15;22(12):4038-43.

3. Juhász T, et al. Cell Signal. 2014 Mar;26(3):468-82.

4. Zhu Y, et al. Sci Rep. 2015 Mar 20;5:9344.

HJC0726 (HJC-0726)

Biological Activity

Physicochemical Properties

References

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