DDD85646 (IMP-366) | NMT1/NMT2 inhibitor

Chemical Structure : DDD85646

CAS No.: 1215010-55-1

DDD85646 (DDD 85646, IMP-366, IMP366)

Catalog No.: PC-62880Not For Human Use, Lab Use Only.

DDD 85646 is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively.

Packing	Price	Stock
5 mg	$298	In stock
10 mg	$458	In stock
25 mg	$758	In stock
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Biological Activity

DDD85646 (IMP-366) is a potent, specific, dual N-Myristoyltransferase NMT1/NMT2 inhibitor with IC50 of 17 nM/22 nM respectively.
DDD 85646 (IMP-366) inhibits myristoylation of an overexpressed protein construct in-cell-based microscopy assays.
DDD 85646 (IMP-366) has no significant affect protein synthesis in cells.
DDD 85646 (IMP-366) causes complete inhibition of N-myristoylation in cells at 1-10 uM.
DDD 85646 (IMP-366) induces ER-stress, cell cycle arrest, and apoptosis in cancer cells.

Physicochemical Properties

M.Wt	495.423
Formula	21H24Cl2N6O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-dichloro-4-(2-(piperazin-1-yl)pyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide

References

1. Thinon E, et al. Nat Commun. 2014 Sep 26;5:4919.

2. Thinon E, et al. ACS Chem Biol. 2016 Aug 19;11(8):2165-76.

3. Brand S, et al. J Med Chem. 2012 Jan 12;55(1):140-52.

4. Wouter W. Kallemeijn, et al. Cell Chem Biol. 2019 Jun 20; 26(6): 892–900.e4.

DDD85646 (DDD 85646, IMP-366, IMP366)

Biological Activity

Physicochemical Properties

References

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