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PSB-12553

Chemical Structure : PSB-12553

CAS No.: 1802226-88-5

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PSB-12553 (PSB12553)

Catalog No.: PC-62917Not For Human Use, Lab Use Only.

PSB-12553 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.5 nM for rat recombinant eN.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PSB-12553 is an α,β-Methylene-ADP (AOPCP) derivative, potent, selective ecto-5′-Nucleotidase (eN, CD73) inhibitor with Ki of 9.5 nM for rat recombinant eN.
    PSB-12553 displays high selectivity versus other ecto-nucleotidases and ADP-activated P2Y receptors, has high metabolic stability.

    Physicochemical Properties

    M.Wt 532.401
    Formula C18H22N4O9P2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (((S)-(((2R,3S,4R,5R)-5-(6-(benzylthio)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid

    References

    1. Bhattarai S, et al. J Med Chem. 2015 Aug 13;58(15):6248-63.

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