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Chemical Structure : OSW-1
CAS No.: 145075-81-6
Catalog No.: PC-62924Not For Human Use, Lab Use Only.
OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively.
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OSW-1 is a natural anti-enterovirus and anti-cancer compound that targets oxysterol-binding protein (OSBP) with Ki of 26 and 54 nM for OSBP and ORP4L, respectively.
OSW-1 potently inhibits the replication of enteroviruses with IC50 values in the low nanomolar range.
OSW-1 exhibits antiproliferative activity in HCT-116 and HeLa cell lines.
| M.Wt | 873.046 | |
| Formula | C47H68O15 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one |
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1. Burgett AW, et al. Nat Chem Biol. 2011 Aug 7;7(9):639-47.
2. Strating JR, et al. Cell Rep. 2015 Feb 3;10(4):600-15.
3. Zhou Y, et al. J Natl Cancer Inst. 2005 Dec 7; 97(23):1781-5.
4. Albulescu L, et al. Antiviral Res. 2015 May;117:110-4.
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