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NY0123

Chemical Structure : NY0123

CAS No.: 1801911-70-5

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NY0123 (NY-0123)

Catalog No.: PC-63104Not For Human Use, Lab Use Only.

NY0123 is a novel potent Exchange proteins directly activated by cAMP (EPAC) antagonist with IC50 of 0.9 and 2.4 uM for EPAC1 and EPAC2, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NY0123 is a novel potent Exchange proteins directly activated by cAMP (EPAC) antagonist with IC50 of 0.9 and 2.4 uM for EPAC1 and EPAC2, respectively.
    NY0123 is more potent than ESI-09.
    NY0123 is a valuable pharmacological probes to facilitate our efforts in elucidating the biological functions of EPAC and developing potential novel therapeutics against human diseases.

    Physicochemical Properties

    M.Wt 399.656
    Formula C16H13Cl3N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(5-tert-Butylisoxazol-3-yl)-2-oxo-N'-(3,4,5-trichlorophenyl)acetohydrazonoyl Cyanide

    References

    1. Ye N, et al. J Med Chem. 2015 Aug 13;58(15):6033-47.

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