| Cat. No. |
Product Name |
Information |
| PC-26778 |
Ligustilide
MEOX1 inhibitor
|
Ligustilide is a potential inhibitor of mesenchyme homeobox 1 (MEOX1), exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects, exerts significant antifibrotic effects through inhibition of MEOX1 and the downstream of the Hippo signalling pathway. |
| PC-26771 |
Kukoamine A
Trypanothione reductase inhibitor
|
Kukoamine A (KuA) is a potent and selective inhibitor of Crithidia fasciculata trypanothione reductase (TR) with Ki of 1.8 uM, with no significant inhibition on human glutathione reductase, possesses antioxidant, anti-inflammatory activities. |
| PC-26770 |
MEDS613
DHODH inhibitor
|
MEDS613 is a potent, selective hDHODH inhibitor with IC50 of 4.1 nM. |
| PC-26769 |
MEDS700
DHODH inhibitor
|
MEDS700 is a potent, selective, blood-brain barrier permeable hDHODH inhibitor with IC50 of 1.5 nM. |
| PC-26766 |
Acetyl-6-formylpterin
MAIT cell inhibitor, MR1 ligand/upregulator
|
Acetyl-6-formylpterin (Ac-6-FP, Acetyl-6-FP) is a small molecule ligand of MHC-related class I-like molecule MR1, markedly stabilizes MR1, potently up-regulates MR1 cell surface expression, and inhibits MAIT cell activation. |
| PC-26765 |
GAA-4OH
DEGS1 inhibitor
|
GAA-4OH is a potent and irreversible inhibitor of dihydroceramide desaturase-1 (DEGS1), covalently blocks the enzyme catalytic cavity, reduces ceramide-to-dihydroceramide ratios and improves steatosis, inflammation, and fibrosis in mouse model of MASLD. |
| PC-26755 |
ELOVL1-IN-2
ELOVL1 inhibitor
|
ELOVL1-IN-2 is a specific ELOVL1 inhibitor with IC50 of 21 μM, inhibits the condensation step of fatty acid elongation and reduces the synthesis of very long-chain fatty acids, including C26:0 VLCFA. |
| PC-26747 |
HNF4α agonist (Z)-19
HNF4α agonist
|
HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM. |
| PC-26745 |
TTBK1/2-IN-1
TTBK1/2 inhibitor
|
TTBK1/2-IN-1 (Compound 3) is a potent tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 816 nM and 384 nM nM for TTBK1 and TTBK2, respectively. |
| PC-26744 |
TTBK1-IN-2
TTBK1 inhibitor
|
TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo. |
| PC-26743 |
TTBK inhibitor 13
TTBK inhibitor
|
TTBK inhibitor 13 (TTBK1/2 inhibitor) is a potent and cell active tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 3 nM and 2.8 nM for TTBK1 and TTBK2, respectively. |
| PC-26724 |
MS351
CBX7 inhibitor
|
MS351 (MS-351) is a specific small molecule antagonist of chromobox 7 (CBX7) chromodomain (CBX7ChD) with Kd of approximately 500 uM by NMR titration, disrupts H3K27me3-mediated CBX7 binding to target genes in chromatin. |
