| Cat. No. |
Product Name |
Information |
| PC-26206 |
164B8
Pin1 degrader
|
164B8 is a highly potent, covalent Pin1 inhibitor / degrader with IC50 of 4.65 nM, reacts with the Pin1 active-site residue Cys113, effectively induces Pin1 degradation both in cell and in vivo. |
| PC-26205 |
CN-0928
PCBP2 inhibitor
|
CN-0928 is a specific small molecule inhibitor of poly(C)-binding protein 2 (PCBP2), mitigates AD pathology by inhibiting PCBP2 condensation. |
| PC-26190 |
4-Methylumbelliferone
Hyaluronan biosynthesis inhibitor
|
4-Methylumbelliferone (4-MU) is a plant-derived coumarin and specific small molecule inhibitor of hyaluronan biosynthesis hyaluronan-mediated motility receptor (HMMR), shows antitumoral and antimetastatic effects. |
| PC-26189 |
Gαi2 inhibitor GT-14
Gαi2 inhibitor
|
GT-14 is a first-generation small molecule inhibitor of Gαi2 protein, inhibits cancer cell migration and prevents Gαi2 activation. |
| PC-26185 |
Biliverdin
114-25-0
|
Biliverdin is a prototypical tetrapyrrolic chromophore compound and HO-1 metabolic product, mediates the protective effects of HO-1 in many disease models including IRI and organ transplantation, exhibits anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant properties. |
| PC-26184 |
WGU55
TMPRSS6 inhibitor
|
WGU55 is a potent, selective peptidomimetic TMPRSS6 inhibitor with Ki of 12.15 nM and IC50 of 138 nM in TMPRSS6-transfected HEK293 cells, shows >200-fold selectivity over matriptase, Factor Xa and Thrombin. |
| PC-26181 |
CAPib-13
CAP-1 inhibitor
|
CAPib-13 is a small-molecule inhibitor of CAP-1 (cyclase-associated protein-1) with SPR KD of 2.57 uM, significantly suppresses colorectal cancer metastasis. |
| PC-26151 |
PLAGL2 inhibitor Compound C8
PLAGL2 inhibitor
|
PLAGL2 inhibitor Compound C8 is a small-molecule inhibitor targeting PLAGL2 (Pleiomorphic adenoma-like protein 2) with SPR KD of 2.23 uM, inhibits PLAGL2 transcriptional activity and HCC cell viability (MHCC-97H, IC50=3.69 uM). |
| PC-26148 |
NFAT Inhibitor VIVIT peptide
NFAT inhibitor
|
NFAT Inhibitor VIVIT peptide is a peptide inhibitor of nuclear factor of activated Tcells (NFAT), selectively inhibits calcineurin-mediated dephosphorylation of NFAT. |
| PC-26147 |
A-285222
NFAT inhibitor
|
A-285222 (A-285) is a bis-trifluoromethyl-pyrazole (BTP) and selective nuclear factor of activated T cells (NFAT) inhibitor, inhibits PBMC proliferation stimulated by concanavalin A with IC50 of 146 nM, inhibits IL-2 synthesis in human blood with IC50 of 182 nM. |
| PC-26146 |
INCA-6
NFAT inhibitor
|
INCA-6 (Inhibitor of NFAT-calcineurin association 6) is a specific, cell-permeable nuclear factor of activated T cells (NFAT) inhibitor, binds to calcineurin with high affinity (KD=0.8 uM) and specifically disrupts its interaction with NFAT. |
| PC-26130 |
SR-1815
SynGAP rescuer
|
SR-1815 is a small molecule multi-kinase inhibitor, rescues SynGAP protein levels in heterozygous KO neurons and in the disease model with Syngap1 haploinsufficiency |
