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Lipoamide

Chemical Structure : Lipoamide

CAS No.: 940-69-2

Lipoamide ((±)-α-Lipoamide)

Catalog No.: PC-24660Not For Human Use, Lab Use Only.

Lipoamide (Alpha-lipoamide) is a neutral derivative of lipoic acid with antioxidant and organ-protective properties, specifically prevents cytoplasmic condensation of stress granule proteins including SRSF1 and SFPQ.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Lipoamide (Alpha-lipoamide) is a neutral derivative of lipoic acid with antioxidant and organ-protective properties, specifically prevents cytoplasmic condensation of stress granule proteins including SRSF1 and SFPQ.
Lipoamide (LAM) has been widely studied as an agent for alleviating various diseases associated with oxidative disruption.
Lipoamide ameliorates aging-associated aggregation of a stress granule reporter protein, improves neuronal morphology and recovers motor defects caused by amyotrophic lateral sclerosis-associated FUS and TDP-43 mutants.

Physicochemical Properties

M.Wt 205.33
Formula C8H15NOS2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(1,2-Dithiolan-3-yl)pentanamide

References

1. Uechi H, Nat Chem Biol. 2025 May 14. doi: 10.1038/s41589-025-01893-5.

2. Tan WL, et al. Biochem Pharmacol. 2025 Apr 12;237:116942.

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