DB2115 tertahydrochloride

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Chemical Structure : DB2115 tertahydrochloride

Catalog No.: PC-24648Not For Human Use, Lab Use Only.

DB2115 tertahydrochloride is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DB2115 tertahydrochloride is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM.
DB2115 decrease cell growth (IC50=3.4 uM) and the clonogenic capacity of AML cells and leads to increased apoptosis, while showing little effect on normal hematopoietic cells.
DB2115 decreases tumor burden and increases survival in murine and human AML transplantation models.

Physicochemical Properties

M.Wt	704.48
Formula	C32H34Cl4N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-((butane-1,4-diylbis(oxy))bis(4,1-phenylene))bis(1H-benzo[d]imidazole-6-carboximidamide) hydrochloride (1:4)

References

1. Antony-Debré I, et al. J Clin Invest. 2017 Oct 30. pii: 92504.

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