IGF2BP1 inhibitor A11

Chemical Structure : IGF2BP1 inhibitor A11

Catalog No.: PC-24649Not For Human Use, Lab Use Only.

IGF2BP1 inhibitor A11 is a specific small molecule insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) inhibitor, binds to IGF2BP) protein with KD of 2.88 nM.

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Biological Activity

IGF2BP1 inhibitor A11 is a specific small molecule insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) inhibitor, binds to IGF2BP) protein with KD of 2.88 nM.
IGF2BP1 inhibitor A11exihibits potent antiproliferative activity against A549 lung cancer cells with IC50 of 9 nM.
A11 might induce autophagy inhibition in A549 tumor cells.
IGF2BP1 inhibitor A11 decreases the expression of downstream apoptosis- and cell cycle-related proteins such as Bcl-2 and Bcl-xl, as well as cell cycle-related proteins such as CDK4 and Cyclin D1.
IGF2BP1 inhibitor A11 (0.5 mg/kg, i.p.) potent anticancer efficacy in an A549 xenograft mouse model with a TGI rate of 80%.

Physicochemical Properties

M.Wt	777.89
Formula	C42H52FN3O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,8S,9R,10R,13R,14S,16R,17R)-17-((R,E)-6-acetoxy-2-hydroxy-6-methyl-3-oxohept-4-en-2-yl)-16-hydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl 2-(4-(4-fluorophenyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetate

References

1. Shang FF, et al. J Med Chem. 2023 Sep 28;66(18):12931-12949.