Chemical Structure : hCES2A inhibitor 9d
CAS No.:
3037959-47-7
hCES2A inhibitor 9d
Catalog No.: PC-24652Not For Human Use, Lab Use Only.
hCES2A inhibitor 9d is a potent, selective and covalent human carboxylesterase 2A (hCES2A) inhibitor with IC50 of 0.12 nM and Ki of 0.43 nM.
Bulk size, bulk discount!
Welcome credit card payment!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
hCES2A inhibitor 9d is a potent, selective and covalent human carboxylesterase 2A (hCES2A) inhibitor with IC50 of 0.12 nM and Ki of 0.43 nM.
hCES2A inhibitor 9d selectively modifies hCES2A at the catalytic serine (Ser228), thereby blocking its catalytic activity.
hCES2A inhibitor 9d shows good cell-membrane permeability and has IC50 of 19.65 nM for inhibiting intracellular hCES2A in living cells.
hCES2A inhibitor 9d (30 mg/kg and 60 mg/kg) significantly promotes ZO-1 and Claudin-1 expression in colon tissues, significantly alleviates irinotecan-induced diarrhea and dextran sulfate sodium-induced colitis.
Physicochemical Properties
|
M.Wt
|
477.60
|
|
Formula
|
C29H35NO5
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
4-methoxy-2-(4-nonanoylbenzofuran-2-yl)phenyl pyrrolidine-1-carboxylate
|
References
1. Danyang Hu, et al. J Med Chem. 2025 May 21. doi: 10.1021/acs.jmedchem.5c00563.
Contact Us
sales@probechem.com
