PF-07853578 | PNPLA3 I148M degrader | Probechem Biochemicals

Chemical Structure : PF-07853578

PF-07853578 (PF 07853578)

Catalog No.: PC-24670Not For Human Use, Lab Use Only.

PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM.

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Biological Activity

PF-07853578 is a covalent inhibitor of patatin-like phospholipase domain-containing protein 3 single nucleotide polymorphism rs738409 148M (PNPLA3-148M), induces PNPLA3 degradation with EC50 of 8 nM.

Physicochemical Properties

M.Wt	408.84
Formula	C16H19ClF2N2O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Piperidinecarboxylic acid, 3,3-difluoro-5-[(5R)-5-methyl-1,1-dioxido-2-isothiazolidinyl]-, 4-chlorophenyl ester, (5R)-

References

1. Patent WO2024084363 A1.

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PF-07853578 (PF 07853578)

Biological Activity

Physicochemical Properties

References

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