Cucurbitacin B | IGF2BP1 inhibitor | Probechem Biochemicals

Chemical Structure : Cucurbitacin B

CAS No.: 6199-67-3

Cucurbitacin B ((+)-Cucurbitacin B)

Catalog No.: PC-24650Not For Human Use, Lab Use Only.

Packing	Price	Stock
5 mg	$78	In stock
10 mg	$118	In stock
25 mg	$198	In stock
50 mg	$298	In stock
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Biological Activity

Cucurbitacin B (CuB) is a potent but toxic anticancer natural product, an irreversible covalent inhibitor of IGF2BP1 and forms a covalent bond with cysteine 253 of the IGF2BP1 KH 1-2 domain (KD=66.8 nM).
Cucurbitacin B inhibits the proliferation of various tumors in vitro and in vivo, including liver cancer, breast cancer, myeloid leukemia, renal cell carcinoma, prostate cancer, non-small cell lung cancer (NSCLC).
Cucurbitacin B destabilizes IGF2BP1-regulated target mRNA and induces tumor cell apoptosis, which in turn attracts immune cells to the tumor microenvironment.

Physicochemical Properties

M.Wt	558.71
Formula	C32H46O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

References

1. Liu Yang, et al. ACS Central Science (2022), 8 (8), 1102-1115.

2. Shang FF, et al. J Med Chem. 2023 Sep 28;66(18):12931-12949.

Cucurbitacin B ((+)-Cucurbitacin B)

Biological Activity

Physicochemical Properties

References

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