Chemical Structure : Core Circadian Modulator
CAS No.:
Core Circadian Modulator
(CCM)
Catalog No.: PC-24661Not For Human Use, Lab Use Only.
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Core Circadian Modulator (CCM) is specific small molecule BMAL1 ligand, targets the cavity in the PASB domain of BMAL1 with ITC Kd of 1.99 uM, modulates BMAL1–CLOCK target gene expressions.
CCM induces dose-dependent alterations in PER2–Luc oscillations and orchestrates the downregulation of inflammatory and phagocytic pathways in macrophages.
Unlike BMAL1 knockdown, CCM treatment preserves BMAL1 protein levels while modulating its transcriptional activity as a pioneer factor.
CCM treatment resulted in decreased expression levels of core TTFL components CRY1, CRY2, PER2 and PER3 while modestly increasing levels of NR1D1, RORA and RORB in U2OS cells
CCM as a highly specific pharmacological tool for understanding the consequences of targeting this pocket in BMAL1–CLOCK functions.
Physicochemical Properties
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M.Wt
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238.26
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Formula
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C13H15FO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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3-((4-ethylbenzofuran-7-yl)oxy)-2-fluoropropan-1-ol
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References
1. Pu H, et al. Nat Chem Biol. 2025 May;21(5):736-745.
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