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GT-02216

Chemical Structure : GT-02216

CAS No.: 2648407-76-3

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GT-02216 (GT02216)

Catalog No.: PC-24677Not For Human Use, Lab Use Only.

GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GT-02216 is a novel allosteric glucocerebrosidase (GCase) modulator with binding KD of 55 uM, enhances GCase activity in primary human fibroblasts, prevents Tau accumulation in GBA1WT and GBA1L444P/L444P cellular models.

Physicochemical Properties

M.Wt 389.46
Formula C22H23N5O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6-amino-4-((2-hydroxyphenyl)amino)pyridin-2-yl)(4-phenylpiperazin-1-yl)methanone

References

1. Matteo Ciccaldo, et al. Sci Rep. 2025 May 21;15(1):17646.

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