| Cat. No. |
Product Name |
Information |
| PC-20459 |
Betulin
SREBP inhibitor
|
Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. |
| PC-20457 |
APC655
ATF6 activator
|
APC655 is a potent activator of protein folding and unfolded protein response (UPR) modulator, APC655 activates ATF6 pathway and chaperone expression. |
| PC-20454 |
Caf1 inhibitor 8j
Caf1 inhibitor
|
Caf1 inhibitor 8j is a potent, selective inhibitor of human poly(A)-selective ribonuclease Caf1 with IC50 of 0.59 uM, 40-fold selectivity over the related deadenylase PARN. |
| PC-20420 |
SC144
gp130 inhibitor
|
SC144 (SC-144) is the first-in-class orally active small-molecule gp130 inhibitor with a broad-spectrum anticancer activity. |
| PC-20404 |
ASP7967
RNA aptamer AC17-4 ligand
|
ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM. |
| PC-20400 |
DHAB
ADPR-cyclase inhibitor
|
DHAB is a potent, specific small molecule inhibitor of kidney ADPR-cyclase with IC50 of 2.5 nM, does not inhibit CD38, spleen, heart or brain ADPR-cyclase activity in vitro. |
| PC-20399 |
SAN4825
ADPR-cyclase inhibitor
|
SAN4825 is a selective small-molecule inhibitor of cardiac ADP-ribosyl cyclase (ADPR cyclase) with IC50 of 0.13 uM. |
| PC-20389 |
Dantrolene
Glutathione reductase inhibitor, RyR antagonist
|
Dantrolene (F368) is a muscle relaxant, non-competitively inhibitor of human erythrocyte glutathione reductase with Ki and IC50 values are 111.6 μM and 52.3 μM, respectively. |
| PC-20384 |
Sulfosuccinimidyl oleate sodium
CD36 inhibitor
|
Sulfosuccinimidyl oleate sodium (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, inhibits fatty acid transport (FAT) into cells. |
| PC-20371 |
PIP5K inhibitor 20
PIP5K inhibitor
|
PIP5K inhibitor 20 is a potent, selective pan-PIP5K inhibitor with IC50 values of 58, 46 and 39 nM for PIP5Kα, PIP5Kβ and PIP5Kγ, respectively. |
| PC-20346 |
SYNTi
Syndecan/syntenin inhibitor
|
SYNTi is a small molecule PDZ domain inhibitor targeting the syndecan/syntenin protein-protein interaction with IC50 of 400 nM. |
| PC-20337 |
TDRL-551
RPA inhibitor
|
TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM. |
