| Cat. No. |
Product Name |
Information |
| PC-38400 |
Inaxaplin
APOL1 inhibitor
|
Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease. |
| PC-38392 |
Farudodstat
DHODH inhibitor
|
Farudodstat (ASLAN003) is a highly potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 35 nM (human DHODH), significantly inhibits protein synthesis via activation AP-1 transcription, induces cell differentiation of AML cell lines. |
| PC-73413 |
Dexfadrostat
Aldosterone synthase inhibitor
|
Dexfadrostat ((R)-Fadrozole, CGS 16949A, FAD286) is a potent nonsteroidal inhibitor of aldosterone synthase (CYP 11B2, steroid 18-hydroxylase), also inhibits human placental aromatase (pIC50=6.17). |
| PC-73396 |
CB253
r(G4C2)exp inhibitor
|
CB253 is a small molecule that selectively binds the hairpin form of r(G4C2)exp, inhibiting mechanisms that drive c9ALS/FTD pathobiology. |
| PC-73386 |
PRG-A01
SOD1 inhibitor
|
PRG-A01 is a chemical inhibitor against SOD1 misfolding and aggregation, inhibits the neuronal cell death caused by mutant-SOD1 overexpression. |
| PC-73320 |
FHD-286
BRG1/BRM inhibitor
|
FHD-286 (FHD286) is a highly potent, selective, allosteric and orally available inhibitor of BRG1 (SMARCA4)/BRM (SMARCA2), dual BRM/ BRG1 inhibitor. |
| PC-73242 |
DS-3801b
GPR38 agonist
|
DS-3801b is a potent, selective, non-macrolide GPR38 agonist for the treatment of functional gastrointestinal disorders. |
| PC-73232 |
Dynein inhibitor 20
Dynein inhibitor
|
Dynein inhibitor 20 is a small moelcule inhibitor of S. cerevisiae dynein by engaging the regulatory ATPase sites in AAA3 and AAA4 domains. |
| PC-73185 |
Hi 76-0079
HSL inhibitor
|
Hi 76-0079 (NNC0076-0079) is a specfic, small molecule inhibitor of hormone-sensitive lipase (HSL) with IC50 of 0.11 uM. |
| PC-73149 |
DLin-MC3-DMA
|
DLin-MC3-DMA is an ionizable amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles. |
| PC-73139 |
ASN 90
O-GlcNAcase inhibitor
|
ASN90 is a potent, selective, substrate-competitive O-GlcNAcase (OGA) inhibitor with IC50 of 10.2 nM. |
| PC-73138 |
KVD900
Plasma kallikrein inhibitor
|
Sebetralstat (KVD900) is a potent,selective, competitive and reversible inhibitor of human plasma kallikrein (PKa) enzyme with Ki of 3.02 nM. |
