| Cat. No. |
Product Name |
Information |
| PC-20014 |
IGGi-11me
GIV-Gαi inhibitor
|
IGGi-11me is a specific, cell-active small molecule inhibitor of GIV-dependent G-protein cell signaling, binds to G-protein α-subunits, specifically disrupts their engagement with GIV/Girdin. |
| PC-20013 |
IGGi-11
GIV-Gαi inhibitor
|
IGGi-11 is a first-in-class small molecule inhibitor of non-canonical activation of heterotrimeric G-protein signaling, binds to G-protein α-subunits (Gαi, Gαi3 ITC Kd=4 uM), specifically disrupts their engagement with GIV/Girdin. |
| PC-20012 |
GCN2iB
GCN2 inhibitor
|
GCN2iB (GCN2 inhibitor) is a potent, selective and ATP-competitive GCN2 inhibitor with IC50 of 2.4 nM. |
| PC-20009 |
FOXM1 inhibitor NB-55
FOXM1 inhibitor
|
FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
| PC-49858 |
Tafamidis
Transthyretin stabilizer
|
Tafamidis is a potent and selective transthyretin (TTR) kinetic stabilizer with EC50 of 2.7-3.2 uM for WT-TTR and mutant tetramers V30M-TTR, V122I-TTR, inhibits amyloidogenesis. |
| PC-49857 |
Acoramidis
Transthyretin stabilizer
|
Acoramidis (AG10) is a potent and selective kinetic stabilizer and ligand of transthyretin (TTR) ligand with apparent binding constant (Kapp) of 193 nM for WT-TTR. |
| PC-49851 |
Nalacin
group II GH3 inhibitor
|
Nalacin is a small molecule that partially mimicks the effects of auxin and potent inhibitor of indole-3-acetic acid (IAA) conjugation mediated by group II GH3 (Gretchen Hagen 3) in vascular plants, inhibits Gretchen Hagen 3 (GH3) acyl acid amido synthetases. |
| PC-49847 |
EP055
Sperm EPPIN inhibitor
|
EP055 (EP-055) is a small molecule that targets epididymal protease inhibitor (EPPIN) on the surface of sperm and inhibits motility (IC50=199.5 uM, CASA assay using human sperm), binds to the C-terminal domain of EPPIN. |
| PC-49819 |
EG-011
WASP activator
|
EG-011 (WASP activator EG-011, EG011) is a first-in-class, small molecule activator of the auto-inhibited form of Wiskott-Aldrich syndrome protein (WASp) with selective anti-tumor activity in lymphomas. |
| PC-49803 |
ClpP agonist TR-65
ClpP agonist
|
ClpP agonist TR-65 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.3 nM. |
| PC-49802 |
ClpP agonist TR-57
ClpP agonist
|
ClpP agonist TR-57 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 15.5 nM. |
| PC-49801 |
ClpP agonist TR-27
ClpP agonist
|
ClpP agonist TR-27 is a potent small molecule agonist of mitochondrial ClpP protease with KD value of 23.7 nM. |
