| Cat. No. |
Product Name |
Information |
| PC-20064 |
GBT601
HbS polymerization inhibitor
|
GBT601 (Osivelotor, GBT021601) is an oral, small molecule, next-generation sickle hemoglobin (HbS) polymerization inhibitor, increases hemoglobin-oxygen (Hb-O2) affinity and stabilizes Hb in the oxy-hemoglobin (oxyHb) state, thereby inhibiting polymerization of HbS in RBCs. |
| PC-20062 |
SBL-105
DHODH inhibitor
|
SBL-105 (SBL105) is a potent, selective DHODH inhibitor with IC50 of 48.48 nM (rh DHODH). |
| PC-20061 |
Nizubaglustat
GCS inhibitor
|
Nizubaglustat (AZ-3102) is a potent, selective inhibitor of glucosylceramide synthase (GCS) with IC50 of 25 nM, inhibits acid glucosylceramidase (GBA1) and neutral glucosylceramidase (GBA2) with IC50 of 200 and 0.08 nM, respectively. |
| PC-20057 |
LY3473329
Lipoprotein (a) inhibitor
|
LY3473329 (Muvalaplin) is a potent, specific, multivalent, orally active disruptor/ inhibitor of lipoprotein(a) (Lp(a)) formation, binds to Kringle IV (KIV)8 domain selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 value of 0.09 nM. |
| PC-20052 |
KISS1-305
KISS1R agonist
|
KISS1-305 is a potent, selective KiSS1-derived peptide receptor (KISS1R) agonist with cellular IC50 of 8.94 nM. |
| PC-20048 |
(R)-SKBG-1
NONO ligand
|
(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation. |
| PC-20028 |
Ederimotide
Wilms tumor protein 1 peptide
|
Ederimotide (WT1-A1) is a synthetic peptide derived from nonamer sequences of the Wilms tumor protein 1 (WT1), increases human T-cell responses and shows potential as cancer vaccine. |
| PC-20027 |
Dibutepinephrine
|
Dibutepinephrine is a sympathomimetic compound. |
| PC-20014 |
IGGi-11me
GIV-Gαi inhibitor
|
IGGi-11me is a specific, cell-active small molecule inhibitor of GIV-dependent G-protein cell signaling, binds to G-protein α-subunits, specifically disrupts their engagement with GIV/Girdin. |
| PC-20013 |
IGGi-11
GIV-Gαi inhibitor
|
IGGi-11 is a first-in-class small molecule inhibitor of non-canonical activation of heterotrimeric G-protein signaling, binds to G-protein α-subunits (Gαi, Gαi3 ITC Kd=4 uM), specifically disrupts their engagement with GIV/Girdin. |
| PC-20012 |
GCN2iB
GCN2 inhibitor
|
GCN2iB (GCN2 inhibitor) is a potent, selective and ATP-competitive GCN2 inhibitor with IC50 of 2.4 nM. |
| PC-20009 |
FOXM1 inhibitor NB-55
FOXM1 inhibitor
|
FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
