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Chemical Structure : BPN-14136
Catalog No.: PC-20718Not For Human Use, Lab Use Only.
BPN-14136 is a potent, selective and non-retinoid RBP4 antagonist with SPA IC50 of 12.8 nM and HTRF IC50 of 43.6 nM.
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BPN-14136 is a potent, selective and non-retinoid RBP4 antagonist with SPA IC50 of 12.8 nM and HTRF IC50 of 43.6 nM.
BPN-14136 does not induce human PXR activation, and displays no significant off-target activity at the hERG channel or within a standard screening panel of fifty-five GPCRs, enzymes, ion channels, and transporters.
BPN-14136 induces a robust and sustained lowering (>90%) of serum RBP4 levels upon 7-day QD oral dosing studies conducted in rats.
| M.Wt | 391.39 | |
| Formula | C20H20F3N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Boglarka Racz, et al. J Biol Chem. 2018 Jul 20;293(29):11574-11588.
2. Cioffi C. L et al. J. Med. Chem. 58, 5863–5888 10.1021/acs.jmedchem.5b00423
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