Chemical Structure : TXX-1-10
CAS No.:
2489250-48-6
TXX-1-10
(CB1-8)
Catalog No.: PC-20699Not For Human Use, Lab Use Only.
TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo.
TXX-1-10 reduces HPIP expression and exerts antiproliferation effect in a HPIP-dependent manner in ZR75-1 cells.
TXX-1-10 exhibites a more effective inhibition compared with rimonabant in MDA-MB-231 and ZR-751 cells (IC50=2.2-7.0 uM).
TXX-1-10 induces G1 cell cycle arrest and apoptosis in breast cancer cells.
TXX-1-10 inhibits breast cancer cell migration and invasion in vitro, regulates genes related to cell proliferation and invasion.
TXX-1-10 (30 mg/kg) suppresses breast tumor growth and metastasis in vivo.
Physicochemical Properties
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M.Wt
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599.68
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Formula
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C23H18Cl3IN4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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CC1=C(N(C2=CC=C(Cl)C=C2Cl)N=C1C(NC3=CC=C[N+](C)=C3)=O)C4=CC=C(C=C4)Cl.[I-]
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References
1. Pengyun Li, et al. Cell Death Discov. 2021 Jul 29;7(1):198.
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