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SN34960

Chemical Structure : SN34960

CAS No.: 1567836-70-7

SN34960 (SN 34960)

Catalog No.: PC-20609Not For Human Use, Lab Use Only.

SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo.

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Purity & Documentation Purity: 99.9% (HPLC) Select Batch:

Biological Activity

SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo.

Physicochemical Properties

M.Wt 506.55
Formula C24H18N4O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)-2-nitrobenzenesulfonamide

References

1. Julie A. Spicer, et al. J. Med. Chem. 2022, 65, 21, 14305–14325

2. M Welz, et al. Nat Commun. 2018 Nov 15;9(1):4805.

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