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Chemical Structure : A1120
CAS No.: 1152782-19-8
Catalog No.: PC-20719Not For Human Use, Lab Use Only.
A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR).
A1120 does not bind to CRBP1 and is selective against a panel of G-protein-coupled receptor, kinase, and enzyme targets.
A1120 binds to RBP4 with higher affinity than either retinol or fenretinide (Ki=125 nM for each).
A1120 (30 mg/kg, oral) decreasers serum RBP4 and retinol levels in B6D2F1 mice, but does not improve insulin sensitivity.
| M.Wt | 392.38 | |
| Formula | C20H19F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid |
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1. Alykhan Motani, et al. J Biol Chem. 2009 Mar 20;284(12):7673-80.
2. Zajc CU, et al. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14926-14935.
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