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A1120

Chemical Structure : A1120

CAS No.: 1152782-19-8

A1120 (A 1120)

Catalog No.: PC-20719Not For Human Use, Lab Use Only.

A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR).
A1120 does not bind to CRBP1 and is selective against a panel of G-protein-coupled receptor, kinase, and enzyme targets.
A1120 binds to RBP4 with higher affinity than either retinol or fenretinide (Ki=125 nM for each).
A1120 (30 mg/kg, oral) decreasers serum RBP4 and retinol levels in B6D2F1 mice, but does not improve insulin sensitivity.

Physicochemical Properties

M.Wt 392.38
Formula C20H19F3N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-(4-(2-(trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

References

1. Alykhan Motani, et al. J Biol Chem. 2009 Mar 20;284(12):7673-80.

2. Zajc CU, et al. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):14926-14935.

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