| Cat. No. |
Product Name |
Information |
| PC-49456 |
CRY1 destabilizer M47
CRY1 destabilizer
|
CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination. |
| PC-49448 |
Eliglustat
GCS inhibitor
|
Eliglustat (GENZ 112638)Eliglustat (GENZ 112638) is a ceramide analog and an orally bioavailable inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase) with IC50 of 20 nM in free-cell assays. |
| PC-49442 |
Connexin hemichannel inhibitor D4
Connexin hemichannel inhibitor
|
Connexin hemichannel inhibitor D4 is an orally available small molecule inhibitor of connexin hemichannels (Cx hemichannel). |
| PC-49430 |
SGPL1 inhibitor THI
SGPL1 inhibitor
|
2-acetyl-5-tetrahydroxybutyl imidazole (SGPL1 inhibitor THI) is a small molecule inhibitor of sphingosine-1- phosphate lyase (SGPL1) reduced cell apoptosis in different in vitro huntington's disease (HD) models. |
| PC-49429 |
Larazotide acetate
Zonulin inhibitor
|
Larazotide acetate (AT1001) is a synthetic, competitive octapeptide inhibitor of zonulin, acts as a tight junction regulator to restore intestinal barrier function. |
| PC-49422 |
Transthyretin stabilizer M-23
Transthyretin stabilizer
|
Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume. |
| PC-49419 |
KIO-100
DHODH inhibitor
|
KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM). |
| PC-49415 |
Compound 14-100
|
Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo. |
| PC-49413 |
UNC-CA157
COQ8A inhibitor
|
UNC-CA157 is a selective small molecule inhibitor of the archetypal UbiB member COQ8A with IC50 of 580 nM, shows clear preference for COQ8A over COQ8B. |
| PC-49405 |
PITPNM3 inhibitor C8018-7840
PITPNM3 inhibitor
|
PITPNM3 inhibitor C8018-7840 is a selective small molecular inhibitor of oncogenic membrane-associated phosphatidylinositol transfer protein 3 (PITPNM3) with binding KD of 500 nM, inhibits CCL18-PITPNM3 signaling mediated cell migration and invasion. |
| PC-49404 |
SMC-21598
CCL8 inhibitor
|
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3. |
| PC-49403 |
cGAS inhibitor 3
cGAS inhibitor
|
cGAS inhibitor 3 is a potent, selective and covalent inhibitor of cyclic GMP-AMP synthase (cGAS) with cellular IC50 of 0.51 uM. |
