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Chemical Structure : FEN1-IN-C20
CAS No.: 824983-94-0
Catalog No.: PC-61813Not For Human Use, Lab Use Only.
FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM。
FEN1-IN-C20 significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin。
FEN1-IN-C20 efficiently suppresses cancer progression in combination with cisplatin in mouse models.
| M.Wt | 393.417 | |
| Formula | C20H15N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3'-((3-hydroxy-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)-[1,1'-biphenyl]-4-carboxamide |
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1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21.
2. He L, et al. Mol Oncol. 2017 Jun;11(6):640-654.
3. He L, et al. EBioMedicine. 2016 Dec;14:32-43.
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