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FEN1-IN-C20

Chemical Structure : FEN1-IN-C20

CAS No.: 824983-94-0

FEN1-IN-C20

Catalog No.: PC-61813Not For Human Use, Lab Use Only.

FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM.

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Biological Activity

FEN1-IN-C20 is an N‐hydroxyl urea derivative that specifically inhibits flap endonuclease 1 (FEN1) activity with IC50 of 3 nM。
FEN1-IN-C20 significantly suppresses cell proliferation and induces DNA damage in lung cancer cells, enhances the therapeutic effect of cisplatin。
FEN1-IN-C20 efficiently suppresses cancer progression in combination with cisplatin in mouse models.

Physicochemical Properties

M.Wt 393.417
Formula C20H15N3O4S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3'-((3-hydroxy-2,4-dioxo-3,4-dihydrothieno[3,2-d]pyrimidin-1(2H)-yl)methyl)-[1,1'-biphenyl]-4-carboxamide

References

1. Exell JC, et al. Nat Chem Biol. 2016 Oct;12(10):815-21.

2. He L, et al. Mol Oncol. 2017 Jun;11(6):640-654.

3. He L, et al. EBioMedicine. 2016 Dec;14:32-43.

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