Cyclocreatine Phosphate (AM 285) is an analog of the creatine kinase CKMT1 substrate creatine and inhibitor of the creatine biosynthesis pathway.
Cyclocreatine Phosphate (AM 285) decreases intracellular ATP level, suppresses arginine-creatine metabolism, selectively decreases the viability, promotes cell cycle arrest and apoptosis of human EVI1-positive AML cells.
Cyclocreatine Phosphate (AM 285) prolongs survival in human orthotopic and mouse primary AML models.
Physicochemical Properties
M.Wt
287.3
Formula
C4H8N3O5P • 2K
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-[imino(phosphonoamino)methyl]-N-methyl-glycine, dipotassium salt
References
1. Woznicki DT, et al. J Neurochem. 1988 May;50(5):1640-7.
2. Turner DM, et al. J Biol Chem. 1987 May 15;262(14):6605-9.
