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Chemical Structure : (S)-FQI1
Catalog No.: PC-62024Not For Human Use, Lab Use Only.
(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.
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(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.
(S)-FQI1 inhibits LSF DNA-binding activity both in vitro, also exhibits antiproliferative activity in multiple cell lines, NIH 3T3, HeLa S3, and A549 cells with GI50 of 0.82, 0.30, and 1.2 uM, respectively.
(S)-FQI1 rapidly induces cell death in QGY-7703 liver cancer cell lines.
| M.Wt | 311.33 | |
| Formula | C18H17NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Grant TJ, et al. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4503-8.
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