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(S)-FQI1

Chemical Structure : (S)-FQI1

CAS No.: 1373209-39-2

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(S)-FQI1 ((S)-FQI 1)

Catalog No.: PC-62024Not For Human Use, Lab Use Only.

(S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    (S)-FQI1 is a small-molecule inhibitor of transcription factor LSF with IC50 of 0.93 uM, approximately 2-fold more active than the racemate FQI-1.
    (S)-FQI1 inhibits LSF DNA-binding activity both in vitro, also exhibits antiproliferative activity in multiple cell lines, NIH 3T3, HeLa S3, and A549 cells with GI50 of 0.82, 0.30, and 1.2 uM, respectively.
    (S)-FQI1 rapidly induces cell death in QGY-7703 liver cancer cell lines.

    Physicochemical Properties

    M.Wt 311.33
    Formula C18H17NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

    References

    1. Grant TJ, et al. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4503-8.

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