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J147

Chemical Structure : J147

CAS No.: 1146963-51-0

J147 (J 147)

Catalog No.: PC-61782Not For Human Use, Lab Use Only.

J 147 is a potent, orally active, memory enhancing and neurotrophic agent that protects against neurotoxicity in cortical neurons in vitro with EC50 of 25-200 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

J147 is a potent, orally active, memory enhancing and neurotrophic agent that protects against neurotoxicity in cortical neurons in vitro with EC50 of 25-200 nM。
J147 reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo, reverses cognitive impairment in aged Alzheimer's disease mice。
J147 improves memory in aged AD mice, which is correlated with its induction of the neurotrophic factors NGF and BDNF as well as several BDNF-responsive proteins which are important for learning and memory.

Physicochemical Properties

M.Wt 350.33
Formula C18H17F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

References

1. Prior M, et al. Alzheimers Res Ther. 2013 May 14;5(3):25.

2. Goldberg J, et al. Aging Cell. 2018 Jan 7. doi: 10.1111/acel.12715.

3. Kim K, et al. Org Biomol Chem. 2015 Oct 7;13(37):9564-9.

4. Chen HY, et al. J Mol Neurosci. 2015 Aug;56(4):977-987.

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