| Cat. No. |
Product Name |
Information |
| PC-72563 |
CC260
PI5P4Kα/β inhibitor
|
CC260 (CC-260) is a potent, selective inhitor of PI5P4Kα/β with Ki of 40/30 nM, respectively. |
| PC-72561 |
GNS561
PPT1 inhibitor
|
GNS561 (Ezurpimtrostat, GNS-561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-72555 |
TET inhibitor C35
TET inhibitor
|
TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome. |
| PC-72554 |
PAX inhibitor BG1
Pax-2 inhibitor
|
PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule inhibitor that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM. |
| PC-72551 |
CTPS-IN-T35
CTPS inhibitor
|
CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays. |
| PC-72550 |
Compound R80
CTPS1 inhibitor
|
Compound R80 (CTPS1-IN-R80) is a potent, selective inhibitor of CTPS1 (cytidine triphosphate synthase 1) with IC50 of 8.4 nM in RapdFire MS assays, >100-fold selectivity over CTPS2 (IC50=4.3 uM). |
| PC-72547 |
SG-094
TPC2 inhibitor
|
SG-094 (SG094) is a specific cytostatic two-pore channel 2 (TPC2) inhibitor with IC50 of 8.3 uM (TPC2 activator TPC2-A1-P inhibition), shows antiproliferative effect on RIL175 cells with IC50 of 3.7 uM. |
| PC-72546 |
SBI-0802936
complex I inhibitor
|
SBI-0802936 (SBI 0802936) is an analog of SMIP004-7, inhibits NADH:ubiquinone oxidoreductase (complex I), 4-6 times more potently than SMIP004-7, acting in the same uncompetitive fashion as SMIP004-7. |
| PC-72545 |
SMIP004-7
complex I inhibitor
|
SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I). |
| PC-72542 |
Compound 2F52
Vaccine adjuvant
|
Compound 2F52 is a synthetic small-molecule vaccine adjuvant for influenza virus infection, activator of innate immunity via mitochondrial stress pathways, acts independently of known TLRs and PRRs. |
| PC-72538 |
DHODH inhibitor GSK983
DHODH inhibitor
|
GSK983 (GSK-983) is a potent small-molecule antiviral agent, and a potent, competitive inhibitor of dihydroorotate dehydrogenase (DHODH) with Ki of 403 nM. |
| PC-72537 |
AL-GDa62
SUMOylation inhibitor
|
AL-GDa62 is a specific inhibitor of TCOF1, ARPC5, and UBC9, inhibits SUMOylation at low micromolar concentrations. |
