| Cat. No. |
Product Name |
Information |
| PC-72651 |
LYS-006
LTA4H inhibitor
|
LYS-006 (LYS006) is a potent, highly selective leukotriene A4 hydrolase (LTA4H) inhibitor with biochemical IC50 <3 nM. |
| PC-72648 |
ASC inhibitor MM01
ASC inhibitor
|
ASC inhibitor MM01 (MM01) is a first-in-class, specific small-molecule inhibitor of ASC protein that interferes with ASC speck formation, inhibited ASC-mediated pro-Casp-1 activation with IC50 of 0.5 uM. |
| PC-72643 |
TRC102
BER inhibitor
|
TRC102 (Methoxyamine HCl, TRC-102) is a small-molecule base-excision repair (BER) inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA. |
| PC-72641 |
STI1
SQOR inhibitor
|
STI1 (SQOR inhibitor STI1) is a potent, specific, competitive inhibitor of human sulfide:quinone oxidoreductase (SQOR) with IC50 of 29 nM. |
| PC-72638 |
AG-270
MAT2A inhibitor
|
AG-270 (AG270) is a highly potent, selective, orally bioavailable MAT2A inhibitor with IC50 of 14 nM. |
| PC-72631 |
AK-3280
Antifibrotic agent
|
AK-3280 (AK 3280, GDC 3280, RG 6069) is an orally available, potential novel anti-fibrotic small molecule under investigation for the treatment of interstitial lung diseases. |
| PC-72609 |
PF-07059013
Hemoglobin modulator
|
PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs. |
| PC-72595 |
YU252
SPAK (STK39) inhibitor
|
YU252 (YU239252) is a small molecule SPAK inhibitor with IC50 of 8.23 uM in in vitro SPAK ELISA assay at 10 uM ATP. |
| PC-72594 |
STOCK1S-14279
SPAK (STK39) inhibitor
|
STOCK1S-14279 (Stock 1S-14279) is a specific small-molecule SPAK kinase (STK39) inhibitor with IC50 of 0.26 uM, inhibits SPAK-regulated phosphorylation and activation of NCC and NKCC1. |
| PC-72593 |
ZT-1a
SPAK (STK39) inhibitor
|
ZT-1a (STK39 inhibitor ZT-1a, SPAK-IN-ZT-1a) is a novel potent, selective SPAK kinase (STK39) inhibitor. |
| PC-72588 |
OSBPL7 inhibitor Cpd A
ABCA1 inducer, OSBPL7 inhibitor
|
ABCA1 inducer Cpd A (Cpd A) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7). |
| PC-72587 |
OSBPL7 inhibitor Cpd G
ABCA1 inducer, OSBPL7 inhibitor
|
ABCA1 inducer Cpd G (Cpd G) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7). |
