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CELF1-IN-27

Chemical Structure : CELF1-IN-27

CAS No.: 58814-55-4

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CELF1-IN-27 (Compound 27)

Catalog No.: PC-72933Not For Human Use, Lab Use Only.

CELF1-IN-27 is a selective CUGBP Elav-like family member 1 (CELF1) inhibitor that disrupted CELF1-RNA binding with IC50 of 23 uM, targets RRM1/2 of CELF1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    CELF1-IN-27 is a selective CUGBP Elav-like family member 1 (CELF1) inhibitor that disrupted CELF1-RNA binding with IC50 of 23 uM, targets RRM1/2 of CELF1.
    CELF1-IN-27 promotes IFN-γ secretion and suppresses TGF-β1-induced hepatic stellate cell (HSC) activation by inhibiting CELF1-mediated IFN-γ mRNA decay, the upregulated antifibrogenic IFN-γ inhibits HSC activation.
    CELF1-IN-2 7attenuates CCl4-induced murine liver fibrosis in vivo.

    Physicochemical Properties

    M.Wt 187.246
    Formula C11H13N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N3,N3-dimethylisoquinoline-1,3-diamine

    References

    1. Yang Tan, et al. Nucleic Acids Res. 2022 Mar 2;gkac139.

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