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Chemical Structure : CELF1-IN-27
Catalog No.: PC-72933Not For Human Use, Lab Use Only.
CELF1-IN-27 is a selective CUGBP Elav-like family member 1 (CELF1) inhibitor that disrupted CELF1-RNA binding with IC50 of 23 uM, targets RRM1/2 of CELF1.
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CELF1-IN-27 is a selective CUGBP Elav-like family member 1 (CELF1) inhibitor that disrupted CELF1-RNA binding with IC50 of 23 uM, targets RRM1/2 of CELF1.
CELF1-IN-27 promotes IFN-γ secretion and suppresses TGF-β1-induced hepatic stellate cell (HSC) activation by inhibiting CELF1-mediated IFN-γ mRNA decay, the upregulated antifibrogenic IFN-γ inhibits HSC activation.
CELF1-IN-2 7attenuates CCl4-induced murine liver fibrosis in vivo.
| M.Wt | 187.246 | |
| Formula | C11H13N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yang Tan, et al. Nucleic Acids Res. 2022 Mar 2;gkac139.
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