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FECH inhibitor 4e

Chemical Structure : FECH inhibitor 4e

CAS No.: 2381246-91-7

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FECH inhibitor 4e (FECH-IN-4e)

Catalog No.: PC-72887Not For Human Use, Lab Use Only.

FECH inhibitor 4e (FECH-IN-4e) is a potent, specifc, competitive inhibitor of ferrochelatase (FECH) with IC50 in the high-nanomolar range.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    FECH inhibitor 4e (FECH-IN-4e) is a potent, specifc, competitive inhibitor of ferrochelatase (FECH) with IC50 in the high-nanomolar range.
    FECH inhibitor 4e inhibited HREC migration in a dose-dependent manner, without cytotoxic effects.
    FECH inhibitor 4e caused statistically significant PPIX accumulation, showed HREC antiproliferative activity.
    Intravitreal injections of FECH inhibitor 4e decreased neovascularization in vivo.

    Physicochemical Properties

    M.Wt 424.508
    Formula C25H24N6O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(4-(tert-Butyl)phenyl)-5-((quinolin-2-ylamino)methyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

    References

    1. Kamakshi Sishtla, et al. Cell Chem Biol. 2022 Jan 25;S2451-9456(22)00001-0.

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