Catalog No.: PC-72885Not For Human Use, Lab Use Only.
LCS3 is a small molecule that selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress, inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively.
LCS3 is a small molecule that selectively impairs the growth of human lung adenocarcinoma (LUAD) cells, induces oxidative stress, inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively.
LCS3 selectively inhibited the growth of 24/25 NSCLC cell lines at low micromolar concentrations (CI50<5 uM), but not the non-transformed lung cell lines (IC50>10 uM).
LCS3 induces ROS and NRF2 pathway activation in sensitive LUAD cells.
LCS3 inhibits glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50 of 3.3 and 3.8 uM, respectively, inhibits GSR through a reversible, uncompetitive mechanism.
LCS3 induces synergistic inhibition of the glutathione and thioredoxin pathways.
Physicochemical Properties
M.Wt
266.637
Formula
C11H7ClN2O4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-chlorophenyl)-5-nitrofuran-2-carboxamide
References
1. Fraser D Johnson, et al. Cell Rep. 2022 Feb 8;38(6):110343.
