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CW5107

Chemical Structure : CW5107

CAS No.:

CW5107 (CW 5107)

Catalog No.: PC-72877Not For Human Use, Lab Use Only.

CW5107 (CW 5107) is a small molecule HSD17B7 inhibitor that enhances oligodendrocyte formation.

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Biological Activity

CW5107 (CW 5107) is a small molecule HSD17B7 inhibitor that enhances oligodendrocyte formation.
CW5107 inhibited HSD17B7 in oligodendrocyte precursor cells (OPCs) with EC50 of 50 nM (4-methylzymostenone and zymostenone accumulation).
CW5107 enhances oligodendrocyte formation at concentrations as low as 25 nM.
CW5107 shows selectivity over other cholesterol pathway enzymes, with no other cholesterol precursors accumulating as detected by GC-MS-based sterol profiling.

Physicochemical Properties

M.Wt 340.278
Formula C16H12F4N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3-(3-fluoro-4-(trifluoromethyl)phenyl)-N-(4-methoxypyridin-2-yl)acrylamide

References

1. Pleshinger MJ, et al. RSC Chem Biol. 2021 Oct 21;3(1):56-68.

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