Catalog No.: PC-72907Not For Human Use, Lab Use Only.
YB-0158 (YB0158) is a β-turn peptidomimetic small molecule altering key hallmarks of human colorectal tumorigenesis, with high predicted affinity for Sam68.
YB-0158 (YB0158) is a β-turn peptidomimetic small molecule altering key hallmarks of human colorectal tumorigenesis, with high predicted affinity for Sam68.
YB-0158 elicits a cancer-selective response impeding main cancer stem cell hallmarks .
YB-0158 blocks icolorectal cancer stem cell activity in tumor organoids and in vivo systems.
Sam68 is a putative target of β-turn peptidomimetic molecules in cancer cells.
Physicochemical Properties
M.Wt
705.61
Formula
C32H34N7O7P.2Na
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2H-Pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide, hexahydro-8-(1H-indazol-7-ylmethyl)-4,7-dioxo-N-(phenylmethyl)-6-[[4-(phosphonooxy)phenyl]methyl]-2-(2-propen-1-yl)-, sodium salt (1:2), (6S,9aS)-
References
1. Angelique N Masibag, et al. iScience. 2021 Nov 14;24(12):103442.
