| Cat. No. |
Product Name |
Information |
| PC-25330 |
Dioctatin
ClpP activator
|
Dioctatin is a small molecule inhibitor of aflatoxin production of Aspergillus flavus, binds to and activates mitochondrial protease ClpP of A. flavus and Escherichia coli. |
| PC-25317 |
PRDX1 inhibitor CP1
PRDX1 inhibitor
|
PRDX1 inhibitor CP1 is a potent, high-affinity small molecule peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 0.08 nM and MST binding Kd of 0.06 nM. |
| PC-25316 |
Conoidin A
PRDX1 inhibitor, TgPrxII inhibitor
|
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties, covalently binds to the peroxidatic Cys47 of TgPrxII and inhibits its hyperperoxidation activity with IC50 of 23 uM, also is a small molecule peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 14.8 uM. |
| PC-25315 |
PRDX1 inhibitor 7e
PRDX1 inhibitor
|
PRDX1 inhibitor 7e (PRDX1-IN-1) is a potent peroxiredoxin 1 (PRDX1) inhibitor with IC50 of 164 nM. |
| PC-25314 |
UNI110
CAS 2648334-60-3
|
UNI110 is a potent small molecule inhibitor of mismatch repair (MMR)-deficient cancer cells, selectively kills MutSa deficient cells with IC50 of 25.05 µM in HEC59 cells and 56.57 µM in HEC59-2 cells. |
| PC-25307 |
SyntOFF
Syntenin inhibitor
|
SyntOFF is a specific small molecule inhibitor of syntenin with IC50 of 37 uM in HTRF assays, targets the PDZ2 domain of syntenin. |
| PC-25283 |
KG022
hairpin RNAs binder
|
KG022 is a fluoroquinolone derivative, binds specifically to the bulge-out region of hairpin RNAs, binds to RNA-C and RNA-G stronger than RNA-A and RNA-U based on the exchange rates. |
| PC-25281 |
KI-DX-014
DDX21 inhibitor
|
KI-DX-014 is a specific small-molecule compound capable of inhibiting the interaction of DDX21 with RNA with IC50 of 3.31 uM, directly binds to DDX21-C-terminal domain (HC+CTD) with Kd of 15.9 uM, allosterically attenuates DDX21 ATPase activity. |
| PC-25280 |
PTC-775
MAPT splicing modulator
|
PTC-775 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 4.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25279 |
PTC-553
MAPT splicing modulator
|
PTC-553 is a potent splicing modulator compound (SMC) with EC2x value of 12.7 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25278 |
PTC-700
MAPT splicing modulator
|
PTC-700 is a potent splicing modulator compound (SMC) with EC2x value of 20.9 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25277 |
PTC-003
MAPT splicing modulator
|
PTC-003 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 5.2 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
