| Cat. No. |
Product Name |
Information |
| PC-23968 |
BPK-25
NuRD inhibitor
|
BPK-25 is a small molecule inhibitor of Nucleosome Remodeling and Deacetylation Complex (NuRD), suppresses T-cell activation at low-μM concentrations without causing cytotoxicity. |
| PC-23950 |
PKRA7
PK2 antagonist
|
PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively. |
| PC-23929 |
CDNB
TrxR inhibitor
|
CDNB is a selective small molecule inhibitor of thioredoxin reductase (TrxR), inhibits TrxR activity with IC50 of 9.4 uM in raw macrophages. |
| PC-23928 |
MitoCDNB
TrxR2 inhibitor
|
MitoCDNB is a mitochondria-targeted molecule that disrupts thiol redox state and inhibits TrxR2, selectively disrupts mitochondrial thiol redox state in cells and in vivo, selectively depletes the mitochondrial GSH pool. |
| PC-23924 |
Nitrobenzylthioinosine
ENT1 inhibitor
|
Nitrobenzylthioinosine (NBMPR) is a specific equilibrative nucleoside transporter 1 (ENT1, SLC29A1)) inhibitor that binds to ENT1 transporter with high affinity. |
| PC-23923 |
Dilazep dihydrochloride
ENT1 inhibitor
|
Dilazep dihydrochloride is a small molecule adenosine reuptake inhibitor (AdoRI) and equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki=151.4 nM), shows cerebral and coronary vasodilating action through enhancement of effect of adenosine. |
| PC-23917 |
JH-ENT-01
ENT1 inhibitor
|
JH-ENT-01 is a potent, specific inhibitor of the equilibrative nucleoside transporter subtype 1 (ENT1) with Ki of 92.7 nM, shows good selectivity for hENT1 over hENT2. |
| PC-23912 |
TN2008
SRSF1 inhibitor
|
TN2008 is an effective serine arginine-rich splicing factor 1 (SRSF1) inhibitor with IC50 of 144 uM, exhibits high affinity for recombinant SRSF1 with Kd of 5.13 uM in SPR assays. |
| PC-23907 |
Norathyriol
CAS 3542-72-1
|
Norathyriol (Mangiferitin) is a natural metabolite of Mangifera, inhibits α-glucosidase in a noncompetitive manner with IC50 of 3.12 uM, also inhibits inhibits PPARα, PPARβ, and PPARγ with IC50 of 90-100 uM, is also an effective inhibitor that targets the MEG pocket on the circPETH-147aa surface. |
| PC-23850 |
ALT-007
Serine palmitoyltransferase inhibitor
|
ALT-007 is a potent, selective and orally bioavailable inhibitor of serine palmitoyltransferase (SPT) with enzyme IC50 of 0.54 nM. |
| PC-23847 |
ZiMo12.8
ZIP12 inhibitor
|
ZiMo12.8 is a small molecule inhibitor of astrocytic zinc transporter ZIP12. |
| PC-23833 |
EOS-984
ENT1 inhibitor
|
EOS-984 is a first-in-class, potent and highly selective inhibitor of equilibrative nucleoside transporter 1 (ENT1), inhibits the immunosuppressive activity of adenosine and restore immune cell proliferation. |
