| Cat. No. |
Product Name |
Information |
| PC-24577 |
MBLAC2 inhibitor KV-79
MBLAC2 inhibitor
|
MBLAC2 inhibitor KV-79 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 24 nM, >60 fold selectivity over HDAC6. |
| PC-24576 |
MBLAC2 inhibitor KV-65
MBLAC2 inhibitor
|
MBLAC2 inhibitor KV-65 is a potent, specific inhibitor of the metalloenzyme MBLAC2 (Metallo-Beta-Lactamase Domain Containing 2) with EC50 of 37 nM, 64-fold selectivity over HDAC6. |
| PC-24553 |
FGH10019
SREBP inhibitor
|
FGH10019 is a specific small molecule inhibitor of sterol regulatory element-binding protein (SREBP) with IC50 of 0.7 uM in SREBP-responsive reporter gene assays. |
| PC-24547 |
Fascin inhibitor G2
Fascin inhibitor
|
Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization. |
| PC-24546 |
NP-G2-029
Fascin inhibitor
|
Fascin inhibitor G2 (NP-G2-029) is a specific small molecule inhibitor of Fascin (FSCN1) with IC50 of 0.19 uM in F-actin-bundling assay. |
| PC-24544 |
Z1362873773
Fascin inhibitor
|
Z1362873773 is a novel small molecule inhibitor of Fascin (FSCN1), reduces the fascin bundling activity. |
| PC-24532 |
DDL-357
Secreted clusterin enhancer
|
DDL-357 is a small molecule secreted isoform of clusterin (sCLU) enhancer with EC50 of 223 nM, increases brain sCLU in the murine ApoE4TR-5XFAD model of AD. |
| PC-24529 |
NUV-244
PNPLA3 I148M degrader
|
NUV-244 is a potent, specific small molecule degrader of PNPLA3 I148M variant, degrades PNPLA3 I148M via the ubiquitin-proteasome system and involving the E3 ligase BFAR. |
| PC-24520 |
GI-Y2
GSDMD inhibitor
|
GI-Y2 (GSDMD inhibitor Y2) is a specific small molecule inhibitor of Gasdermin D (GSDMD), directly interacts with the Arg10 residue of GSDMD (SPR KD=36.0 uM) and reduces the membrane binding of N‐terminal domain (GSDMD‐N). |
| PC-24478 |
CLEC-2 inhibitor MAS9
CLEC-2 inhibitor
|
MAS9 is a specific small molecule inhibitor targeting the C-type lectin-like receptor-2 (CLEC-2)-podoplanin interaction with IC50 of 4.5 uM, inhibits CLEC-2-mediated platelet aggregation. |
| PC-24463 |
FICD inhibitor C22
FICD inhibitor
|
FICD inhibitor C22 is a specific, cell-permeable inhihitor of the AMP transferase FICD, significantly inhibits endogenous FICD-mediated BiP AMPylation (IC50=7.27 uM) while weakly inhibiting BiP deAMPylation. |
| PC-24451 |
Mitochondrial complex I inhibitor C458
CAS 2001090-87-3
|
C458 is nontoxic mitochondrial complex I (mtCI) inhibitor with highly protective against Aβ toxicity, C458 protects MC65 Tet-Off cells (Aβ expressed) with an EC50 of 4.6 nM. |
