| Cat. No. |
Product Name |
Information |
| PC-25277 |
PTC-003
MAPT splicing modulator
|
PTC-003 is a potent splicing modulator compound (SMC) that correct microtubule-associated protein tau (MAPT) splicing with EC2x value of 5.2 nM in MAPT minigene assay in HEK293T cells (3R MAPT), promotes MAPT exon 10 exclusion, increasing 3R MAPT transcript and protein levels. |
| PC-25275 |
Cycloleucine
MAT2A inhibitor
|
Cycloleucine is a specific inhibitor of S-adenosyl-methionine mediated methylation, is also a competitive inhibitor of ATP: L-methionine-S-adenosyl transferase in vitro, also inhibits MAT2A, Cycloleucine is an antagonist of NMDA receptor associated glycine receptor. |
| PC-25274 |
AGI-24512
MAT2A inhibitor
|
AGI-24512 is a highly potent, cell-active methionine adenosyltransferase 2α (MAT2A) inhibitor with enzymatic IC50 of 8 nM. |
| PC-25267 |
Ac5GlutolNAc
RENBP inhibitor
|
Ac5GlutolNAc is a specific small molecule inhibitor of GlcNAc 2-epimerase (RENBP), selectively enhances the labeling efficiency of tetraacetyl-N-azidoacetylmannosamine (AAM) in antigen-presenting cells (APCs), but not non-APCs. |
| PC-25260 |
IPR-3242
uPAR-uPA inhibitor
|
IPR-3242 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, inhibits the uPAR·uPAATF interaction with IC50 of 8.6 uM. |
| PC-25259 |
IPR-803
uPAR-uPA inhibitor
|
IPR-803 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds directly to uPAR with sub-micromolar affinity of 0.2 uM. |
| PC-25258 |
IPR-456
uPAR-uPA inhibitor
|
IPR-456 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds to uPAR with Kd of 310 nM, inhibits uPA binding to uPAR of breast MDA-MB-231 tumor cells with IC50 of 8 uM. |
| PC-25256 |
Profilin-1 inhibitor UP-6
Profilin-1 inhibitor
|
Profilin-1 inhibitor UP-6 is a specific small molecule inhibitor of actin-binding protein profilin-1 (Pfn1), inhibits Pfn1-actin interaction and shows potent anti-angiogenic activity in vitro and in vivo. |
| PC-25255 |
Pfn1-actin interaction inhibitor C74
Profilin-1 inhibitor
|
Pfn1-actin interaction inhibitor C74 is a specific small molecule inhibitor of profilin1 (Pfn1)-actin interaction, reduces RCC cell proliferation in vitro and tumor growth in vivo. |
| PC-25254 |
Pfn1-actin interaction inhibitor C2
Profilin-1 inhibitor
|
Pfn1-actin interaction inhibitor C2 is a specific small molecule inhibitor of profilin1 (Pfn1)-actin interaction, inhibits the angiogenic ability of vascular endothelial cells (ECs), affects the actin cytoskeleton, migration, and proliferation of Ecs. |
| PC-25253 |
Pfn1-actin interaction inhibitor C1
Profilin-1 inhibitor
|
Pfn1-actin interaction inhibitor C2 is a specific small molecule inhibitor of profilin1 (Pfn1)-actin interaction, inhibits the angiogenic ability of vascular endothelial cells (ECs), affects the actin cytoskeleton, migration, and proliferation of ECs. |
| PC-25248 |
FLIX5
EPLIN inhibitor
|
FLIX5 (NSC328403, 4-Formylcolchicine) is a specific small molecule targeting EPLIN (Epithelial Protein Lost In Neoplasm), binds stably to EPLIN and exhibits broad cytotoxicity against both neuroblastoma and medulloblastoma cells, primarily by triggering apoptosis. |
