| Cat. No. |
Product Name |
Information |
| PC-42082 |
TPEN
LIN28 inhibitor
|
TPEN (TPEDA) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM, also is a specific cell-permeable heavy metal chelator. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-25568 |
ELOVL6 inhibitor 1w
ELOVL6 inhibitor
|
ELOVL6 inhibitor 1w (ELOVL6-IN-4) is a potent, selective, and orally available ELOVL6 (long chain fatty acid elongase 6) inhibitor with IC50 of 79 and 94 nM for human and mouse ELOVL6 respectively. |
| PC-25561 |
BI 1595043
Vanin inhibitor
|
BI 1595043 is a potent, selective and orally bioavailable Vanin (vanin‐1 and vanin‐2) inhibitor, demonstrates promising effects on epithelial cell protection and reduction of inflammatory mediators in preclinical studies. |
| PC-25558 |
KCB3602
Lin28-let-7 inhibitor
|
KCB3602 is a specific small-molecule inhibitor of the Lin28–let-7 interaction with IC50 of 4.8 uM in EMSA assays, shows direct binding to Lin28a with SPR KD of 5.9 uM. |
| PC-25556 |
α-difluoromethylornithine
Ornithine decarboxylase inhibitor
|
α-difluoromethylornithine (DFMO, Eflornithine, MDL71782) is a specific, irreversible inhibitor of polyamine biosynthesis enzyme Ornithine decarboxylase (ODC) with biochemicals IC50 of 252 uM, binding competitively with ornithine. |
| PC-25540 |
Ezurpimtrostat hydrochloride
PPT1 inhibitor
|
Ezurpimtrostat hydrochloride (GNS561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-25528 |
MDOLL-0286
ARH3 inhibitor
|
MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1. |
| PC-25526 |
MSC778
FEN1 inhibitor
|
MSC778 (MSC-778) is a potent, selective, and orally bioavailable inhibitor of Flap endonuclease 1 (FEN1) with IC50 of 3.0 nM and SPR KD of 2.9 nM, >65-fold selective over closely related RAD2 family members EXO1, GEN1 and XPG. |
| PC-25516 |
iOXCT1
OXCT1 inhibitor
|
iOXCT1 (D574-0246) is a specific small molecule 3-Oxoacid CoA-transferase 1 (OXCT1) inhibitor, inhibits the dual enzymatic ketolytic and succinyltransferase activities of OXCT1 specifically. |
| PC-25481 |
W1122
SNX3 inhibitor
|
W1122 is a specific small-molecule inhibitor of Sorting nexin 3 (SNX3). |
| PC-25479 |
SF-153
UHM inhibitor
|
SF-153 is a small molecule inhibitor of UHM splicing factor RBM39 and SPF45 with IC50 of 45.8 uM for both, targets U2 Auxiliary Factor Homology Motif (UHM) domains, exerts anti-tumor activities in leukemia cell lines. |
