Chemical Structure : FLIX5
CAS No.:
2730-82-7
FLIX5
(NSC328403, 4-Formylcolchicine)
Catalog No.: PC-25248Not For Human Use, Lab Use Only.
FLIX5 (NSC328403, 4-Formylcolchicine) is a specific small molecule targeting EPLIN (Epithelial Protein Lost In Neoplasm), binds stably to EPLIN and exhibits broad cytotoxicity against both neuroblastoma and medulloblastoma cells, primarily by triggering apoptosis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
FLIX5 (NSC328403, 4-Formylcolchicine) is a specific small molecule targeting EPLIN (Epithelial Protein Lost In Neoplasm), binds stably to EPLIN and exhibits broad cytotoxicity against both neuroblastoma and medulloblastoma cells, primarily by triggering apoptosis.
FLIX5 impairs mitochondrial function and increases the dependency of neuroblastoma cells on lipid metabolism.
FLIX5 prefers to bind to EPLIN compared to SRRD and SLTM.
FLIX5 enhances the cholesterol dependency of neuroblastoma cells under conditions where mitochondrial function is impaired.
FLIX5 induces p53-independent induction of apoptosis.
FLIX5 synergizes with conventional chemotherapy in the treatment of neuroblastoma, shows selectivity between normal and cancer cells.
Physicochemical Properties
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M.Wt
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427.45
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Formula
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C23H25NO7
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Acetamide, N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
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References
1. Lindell E, et al. Cell Death Dis. 2025 Jul 23;16(1):554.
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