IPR-456 | uPAR-uPA inhibitor | Probechem Biochemicals

Chemical Structure : IPR-456

IPR-456 (IPR456)

Catalog No.: PC-25258Not For Human Use, Lab Use Only.

IPR-456 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds to uPAR with Kd of 310 nM, inhibits uPA binding to uPAR of breast MDA-MB-231 tumor cells with IC50 of 8 uM.

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Biological Activity

IPR-456 is a small molecule inhibitor of the uPAR·uPA protein-protein interaction, binds to uPAR with Kd of 310 nM, inhibits uPA binding to uPAR of breast MDA-MB-231 tumor cells with IC50 of 8 uM.

Physicochemical Properties

M.Wt	467.53
Formula	C28H25N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((3-(3,5-Dimethylpiperidin-1-yl)-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)amino)benzoic acid

References

1. Khanna M, et al. ACS Chem Biol. 2011 Nov 18;6(11):1232-43.

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IPR-456 (IPR456)

Biological Activity

Physicochemical Properties

References

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