| Cat. No. |
Product Name |
Information |
| PC-21416 |
HQY426
CPSF3 inhibitor
|
HQY426 is a specific, orally bioavailable inhibitor of pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3 (CPSF3) with binding IC50 of 0.32 uM, exhibits potent antitumor activity. |
| PC-21410 |
LY3522348
Ketohexokinase (KHK) inhibitor
|
LY3522348 is a potent, highly selective, oral dual inhibitor of human ketohexokinase isoforms C and A (hKHK-C, hKHK-A) with IC50 of 20 nM and 24 nM, respectively. |
| PC-21385 |
PXS-5505 dihydrochloride monohydrate
pan-LOX inhibitor
|
PXS-5505 dihydrochloride monohydrate is an orally available, small-molecule, irreversible inhibitor of all lysyl oxidases (pan-LOX) family members, with potential antifibrotic activity. |
| PC-21363 |
IGF2BP3 inhibitor AE-848
IGF2BP3 inhibitor
|
IGF2BP3 inhibitor AE-848 is a small molecule inhibitor of RNA m6A reader insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), inhibits the growth and progression of OC cells by disrupting the stability of the targeted mRNAs of IGF2BP3. |
| PC-21350 |
IP-DNQ
NQO1 inhibitor
|
IP-DNQ (Isopentyl-deoxynboquinone) is a small molecule that selectively kills pancreatic ductal adenocarcinoma cells in an NQO1-dependent manner. |
| PC-21347 |
Karyostatin 1A
Importin β inhibitor
|
Karyostatin 1A is a small molecule inhibitor of importin beta with binding affinity (Kd=0.3 uM), selectively inhibits the importin α/β pathway. |
| PC-21343 |
GPR101 agonist AA-14
GPR101 agonist
|
GPR101 agonist AA-14 is a specific small molecule agonist of GPR101 with EC50 of 0.37 uM, 0.88 uM and 2.14 uM in activating Gs, Gq or β-arrestin2 assays respectively. |
| PC-21325 |
MV-658
ENPP1 inhibitor
|
MV658 (ENPP1-IN-1) is a potent small molecule ENPP1 inhibitor (IC50= 11 nM) as immune modulator. |
| PC-21313 |
HsClpP activator ZK53
HsClpP activator
|
HsClpP activator ZK53 is a potent, selective activator of mitochondrial caseinolytic protease P (HsClpP) with EC50 of 0.22 uM in FI-based protease activity assays, inactive toward bacterial ClpP proteins. |
| PC-21299 |
2-MPPA
GCP-II Inhibitor
|
2-MPPA (GPI-5693) is a potent, selective and orally active glutamate carboxypeptidase II (GCP II, NAALADase) inhibitor with IC50 of 90 nM. |
| PC-21294 |
NVS1.1
eRF1 inhibitor
|
NVS1.1 is a potent readthrough promoter, promotes the rapid and specific degradation of eukaryotic release factor 1 (eRF1) and restores functional full-length proteins in cystic fibrosis and Hurler disease models. |
| PC-21278 |
MSN-CD44 inhibitor 2
CD44-MSN inhibitor
|
MSN-CD44 inhibitor 2 is a small molecule FERM domain protein-protein interaction inhibitor for moesin (MSN) and CD44 with SPR KD of 0.7 uM, is a potent inhibitor of CD44-MSN interaction in live cells with IC50 of 200 nM. |
