| Cat. No. |
Product Name |
Information |
| PC-20258 |
Dichloroallyl lawsone
DHODH inhibitor
|
Dichloroallyl lawsone (Dichlorolapachol, DCL, NSC-126771) is a synthetic analogue of the antimalarial lapachol, inhibits mitochondrial dihydroorotate dehydrogenase (DHODH) with antineoplastic activity. |
| PC-20214 |
MIF2 inhibitor 5d
MIF-2 inhibitor
|
MIF2 inhibitor 5d is a selective inhibitor of d-dopachrome tautomerase (d-DT or MIF2) with IC50 of 1.0 μM for MIF2 tautomerase activity and a high selectivity over MIF. |
| PC-20196 |
ψTnI
cTnI/PKCδ inhibitor
|
ψTnI (Peptide DWRKNIDA) is a selective, high-affinity, eight amino acid peptide inhibitor of cardiac troponin I (cTnI), directly binds to δPKC with high affinity (Kd=5 nM) and inhibits cTnI/δPKC interaction. |
| PC-20156 |
(S)-CKi-1
Covalent creatine kinase inhibitor
|
(S)-CKi-1 is a selective, covalent inhibitor of creatine kinases (CKs), inhibits recombinant creatine kinase B (CKB) phosphotransfer activity with IC50 of 0.6 uM, depletes creatine phosphagen energetics in cells. |
| PC-20117 |
UFSP2 inhibitor compound-8
UFSP2 inhibitor
|
UFSP2 inhibitor compound-8 is a small molecule covalent inhibitor of UFSP2, binds to Cys294 of UFSP2, promotes the protein modification by Ubiquitin-fold modifier 1 (UFM1) (UFMylation) of PD-L1 and destabilizes PD-L1. |
| PC-20116 |
MIDI
Mitochondrial fission inhibitor
|
MIDI (Mitochondrial division inhibitor) is a potent, covalent mitochondrial fission inhibitor, interacts with DRP1-C367 to block mitochondrial fission. |
| PC-20057 |
LY3473329
Lipoprotein (a) inhibitor
|
LY3473329 (Muvalaplin) is a potent, specific, multivalent, orally active disruptor/ inhibitor of lipoprotein(a) (Lp(a)) formation, binds to Kringle IV (KIV)8 domain selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 value of 0.09 nM. |
| PC-20048 |
(R)-SKBG-1
NONO ligand
|
(R)-SKBG-1 is a covalent small molecule ligand of RNA-binding protein NONO, engages NONO Cys145 and suppress an array of cancer-relevant genes and impair cancer cell proliferation. |
| PC-20009 |
FOXM1 inhibitor NB-55
FOXM1 inhibitor
|
FOXM1 inhibitor NB-55 is a small molecule inhibitor of transcription factor FOXM1 with Ki value of 230 nM and IC50 of 1.24 uM, bind directly to FOXM1 and alter its proteolytic sensitivity, reduces the cellular level of FOXM1 protein. |
| PC-49788 |
DHODH inhibitor M62
DHODH inhibitor
|
DHODH inhibitor M62 is a potent, selective dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 6.9 nM. |
| PC-49783 |
JNJ-DHODH-IN-29
DHODH inhibitor
|
JNJ-DHODH-IN-29 is a potent, selective DHODH inhibitor with IC50 of 0.3 nM, inhibits MOLM-13 cell proliferation with IC50 of 0.4 nM. |
| PC-49782 |
JNJ-DHODH-IN-19
DHODH inhibitor
|
JNJ-DHODH-IN-19 is a potent, selective DHODH inhibitor with IC50 of 1.1 nM, inhibits MOLM-13 cell proliferation with IC50 of 2.0 nM. |
