Cat. No. |
Product Name |
Information |
PC-20719 |
A1120
RBP4 inhibitor
|
A1120 is a high affinity, non-retinoid ligand for retinol-binding protein 4 (RBP4) with Ki of 8.3 nM, disrupts the interaction between RBP4 and its binding partner transthyretin (TTR). |
PC-20609 |
SN34960
Perforin inhibitor
|
SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. |
PC-20604 |
Auranofin
TrxR inhibitor, UBA1 enhancer
|
Auranofin (SKF39162) is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer. |
PC-20567 |
PF-04859989
Kynurenine aminotransferase II inhibitor
|
PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively. |
PC-20490 |
R805
gp130 modulator
|
R805 is a small molecule modulator of gp130 receptor pro-inflammatory signaling, targets a signaling tyrosine 814 (Y814) within gp130, modulates gp130 Y814 upstream of the SRC and MAPK circuit, elicits a protective effect on tissues after injury. |
PC-20459 |
Betulin
SREBP inhibitor
|
Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig. |
PC-20457 |
APC655
ATF6 activator
|
APC655 is a potent activator of protein folding and unfolded protein response (UPR) modulator, APC655 activates ATF6 pathway and chaperone expression. |
PC-20404 |
ASP7967
|
ASP7967 (ASP-7967) is a cell-permeable and low-toxic compound of RNA aptamer AC17-4 with SPR binding Kd of 12 nM, activates gene expression (>10-fold) in aptazyme-based riboswitches with EC50 of 2.3 uM. |
PC-20337 |
TDRL-551
RPA inhibitor
|
TDRL-551 (TDRL551) is a small molecule Replication Protein A (RPA) inhibitor targeting the Replication Protein A-DNA interaction with IC50 of 18 uM. |
PC-20325 |
HTL0041178
GPR52 agonist
|
HTL0041178 is a potent GPR52 agonist with EC50 of 27.5 nM (human or rat GPR52). |
PC-20318 |
Secdin
ARF-GEF inhibitor
|
Secdin is a small-molecule inhibitor of Arabidopsis thaliana ADP-ribosylation factor (ARF)-guanine nucleotide exchange factors (GEFs), impaires both hypocotyl and root growth in young Arabidopsis seedlings with IC50 of 4 uM. |
PC-20306 |
ELOVL6 inhibitor Compound B
ELOVL6 inhibitor
|
ELOVL6 inhibitor Compound B is a potent and selective ELOVL6 inhibitor with IC50 of 85 and 38 nM for human and mouse ELOVL6, respectively. |