Chemical Structure : HF13141-H5
CAS No.:
688738-27-4
HF13141-H5
Catalog No.: PC-26237Not For Human Use, Lab Use Only.
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HF13141-H5 is a potent, selective inhibitor of γ-Glutamyl carboxylase (GGCX) with IC50 of 240 nM-1 uM in cell-based assays, inhibits γ-carboxylation of vitamin K-dependent clotting factors (VKDCFs) and shows anticoagulant effect.
HF13141-H5 specifically inhibits GGCX activity without affecting vitamin K epoxide reductase (VKOR) function.
HF13141-H5 inhibited vitamin K epoxidation in a dose dependent manner, completely abolishing epoxidation activity at 20 uM in in vitro vitamin K epoxidation activity assay.
HF13141-H5 competitively inhibits GGCX by occupying the KH2 substrate-binding pocket.
HF13141-H5 mimics the binding of reduced vitamin K.
HF13141-H5 maintained full inhibitory potency against VKOR variants associated with warfarin resistance and demonstrated robust anticoagulant activity in a zebrafish laser-induced endothelial injury model.
Physicochemical Properties
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M.Wt
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415.45
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Formula
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C24H21N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(1-oxophthalazin-2(1H)-yl)ethyl (4-(benzyloxy)phenyl)carbamate
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References
1. Guomin Shen, et al. Blood Adv. 2025 Dec 22:bloodadvances.2025018776.
2. Patent CN113831293 A 2021-12-24.
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