Chemical Structure : IVMT-Rx-4
CAS No.:
2847084-93-7
IVMT-Rx-4
Catalog No.: PC-26386Not For Human Use, Lab Use Only.
IVMT-Rx-4 is a small molecule inhibitor of MDA-9/Syntenin, specifically interrupt MDA-9/Syntenin signaling, leading to an inhibition in progression of PC cells to bone metastasis.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
IVMT-Rx-4 is a small molecule inhibitor of MDA-9/Syntenin, specifically interrupt MDA-9/Syntenin signaling, leading to an inhibition in progression of PC cells to bone metastasis.
IVMT-Rx-4 is a synthetic intermediate of MDA-9/Syntenin antagonist PDZ1i, exhibits greater efficacy compared to PDZ1i.
IVMT-Rx-4 inhibits NF-κB activation and PDGF-AA expression in different PC cell lines.
IVMT-Rx-4 inhibits PDGF-AA-induced CXCL5 expression in bone marrow derived mesenchymal stromal cells (BM-MSCs).
IVMT-Rx-4 (30 mg/kg body weight) inhibits experimental bone metastasis and enhances animal survival, the combination of IVMT-Rx-4 and docetaxel enhances survival in experimental bone metastasis models.
Physicochemical Properties
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M.Wt
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336.40
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Formula
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C19H20N4O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-amino-2,5-dimethylphenyl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanamide
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References
1. Maji S, et al. Pharmacol Res. 2026 Mar 20:108164.
2. Kegelman TP, et al. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):370-375.
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