| Cat. No. |
Product Name |
Information |
| PC-63261 |
HZ05
DHODH inhibitor
|
HZ05 is a potent DHODH inhibitor with IC50 of 32 nM, accumulates cancer cells in S-phase, increases p53 synthesis, and synergizes with an inhibitor of p53 degradation (Nutlin-3a) to reduce tumor growth in vivo.. |
| PC-63249 |
JBSNF-000088
NNMT inhibitor
|
JBSNF-000088 (6-Methoxynicotinamide) is a small molecule nicotinamide analog that inhibits Nicotinamide N-methyltransferase (NNMT) with IC50 of 1.8, 2.8 and 5.0 µM for human, monkey and mouse NNMT, respectively. |
| PC-63248 |
BI-1935
sEH inhibitor
|
BI-1935 is a potent, selective small molecule inhibitor of soluble epoxide hydrolase (sEH) with IC50 of 7 nM. |
| PC-63244 |
Bractoppin
|
Bractoppin is a potent, small-molecule chemical inhibitor that specific selectively blocks phosphopeptide recognition by the BRCA1 tBRCT domain with binding IC50 of 74 nM. |
| PC-43248 |
EN460
ERO1 inhibitor
|
EN460 is a specific mall molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1), interacts selectively with the reduced, active form of ERO1α and prevents its reoxidation (IC50=1.9 uM). |
| PC-43236 |
Sortin1
Sorting inhibitor
|
Sortin1 is a small molecule sorting inhibitor (Sortin) that induces reversible defects in vacuole biogenesis and root development in Arabidopsis seedlings at 100 mg/liter (227 uM). |
| PC-43219 |
AF38469
Sortilin inhibitor
|
AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM. |
| PC-43171 |
Genz-123346
Glucosylceramide synthase inhibitor
|
Genz-123346 is a potent, specific glucosylceramide synthase (GCS) inhibitor with IC50 of 14 nM (GM1 inhibition), does not inhibit α-glucosidase or glucocerebrosidase and little effect on 1-O-acylceramide synthase activity. |
| PC-43170 |
Genz-123346 free base
Glucosylceramide synthase inhibitor
|
Genz-123346 is a potent, specific glucosylceramide synthase inhibitor with IC50 of 14 nM (GM1 inhibition), does not inhibit α-glucosidase or glucocerebrosidase and little effect on 1-O-acylceramide synthase activity. |
| PC-63195 |
RCGD 423
gp130 modulator
|
RCGD 423 (RCGD423) is a small molecule gp130 modulator that prevents articular cartilage degeneration and promotes repair both in vitro and in vivo. |
| PC-42996 |
FH1
|
FH1 (BRDK4477) is a small molecule that increase function and proliferation of primary human hepatocytes, promotes the differentiation of iPS-derived hepatocytes. |
| PC-42915 |
PFK15
PFKFB3 inhibitor
|
PFK15 (PFK 015) is a potent, selective 6-phosphofructo-2-kinase (PFKFB3) inhibitor with IC50 of 207 nM against recombinant human PFKFB3, displays 100-fold more activity than 3PO. |
