| Cat. No. |
Product Name |
Information |
| PC-72664 |
DS96432529
Bone anabolic agent
|
DS96432529 (DS 96432529) is a potent and orally active bone anabolic agent with EC200 value of 0.024 ug/mL. |
| PC-72661 |
Vanin-1 inhibitor 2
Vanin-1 inhibitor
|
Vanin-1 inhibitor 2 is a potent, selective, oral Vanin-1 inhibitor with IC50 of 3.4 and 1.5 nM for human and mouse Vanin-1, respectively. |
| PC-72660 |
PFI-653
Vanin-1 inhibitor
|
PFI-653 (Vanin-1-IN-1) is a highly potent vanin-1 inhibitor with IC50 of 6.8 nM (human Vanin-1). |
| PC-72652 |
JNJ-40929837
LTA4H inhibitor
|
JNJ-40929837 (JNJ40929837) is a potent, highly selective, oral leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 1.9 nM, demonstrates high potency (IC50=48 nM) in human whole blood ionophore-stimulated LTB4 release assay. |
| PC-72651 |
LYS-006
LTA4H inhibitor
|
LYS-006 (LYS006) is a potent, highly selective leukotriene A4 hydrolase (LTA4H) inhibitor with biochemical IC50 <3 nM. |
| PC-72648 |
ASC inhibitor MM01
ASC inhibitor
|
ASC inhibitor MM01 (MM01) is a first-in-class, specific small-molecule inhibitor of ASC protein that interferes with ASC speck formation, inhibited ASC-mediated pro-Casp-1 activation with IC50 of 0.5 uM. |
| PC-72643 |
TRC102
BER inhibitor
|
TRC102 (Methoxyamine HCl, TRC-102) is a small-molecule base-excision repair (BER) inhibitor, potentiates the cytotoxicity of pemetrexed and reverses resistance by binding to chemotherapy-induced abasic sites in DNA. |
| PC-72641 |
STI1
SQOR inhibitor
|
STI1 (SQOR inhibitor STI1) is a potent, specific, competitive inhibitor of human sulfide:quinone oxidoreductase (SQOR) with IC50 of 29 nM. |
| PC-72638 |
AG-270
MAT2A inhibitor
|
AG-270 (AG270) is a highly potent, selective, orally bioavailable MAT2A inhibitor with IC50 of 14 nM. |
| PC-72631 |
AK-3280
Antifibrotic agent
|
AK-3280 (AK 3280, GDC 3280, RG 6069) is an orally available, potential novel anti-fibrotic small molecule under investigation for the treatment of interstitial lung diseases. |
| PC-72609 |
PF-07059013
Hemoglobin modulator
|
PF-07059013 (PF 07059013) is a potent, noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity (Ki=0.6 nM) and displays strong partitioning into RBCs. |
| PC-72595 |
YU252
SPAK (STK39) inhibitor
|
YU252 (YU239252) is a small molecule SPAK inhibitor with IC50 of 8.23 uM in in vitro SPAK ELISA assay at 10 uM ATP. |
